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Genetic and molecular control of circadian behaviour in higher eukaryotes [clock, neurons, molecular, polymorphism]

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  • Full or part time
    Prof Kyriacou
    Dr Rosato
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (UK Students Only)
    Competition Funded PhD Project (UK Students Only)

Project Description

We study complex behaviour in higher organisms in Drosophila focusing on circadian rhythms which are ubiquitous features that are under genetic control. Mutations in several genes in Drosophila melanogaster alter the normal circadian functioning of the fly and we have been analysing these genes at the molecular level. We are also dissecting the roles of individual clock neurons in the network that generates rhythmicity, and also studying how photoreceptors are involved in entraining the clock to the normal solar day. In this project, we are particularly interested in seeing how flies behave in the wild, and how the circadian molecules respond to natural environmental changes.




We are an equal opportunities employer and particularly welcome applications for Ph.D. places from women, minority ethnic and other under-represented groups.

References

Vanin S, et al. 2012 Unexpected features of Drosophila circadian behavioural rhythms under natural conditions. Nature, 484, 371-6
Green, E.W., et al (2014) Widely used Drosophila RNAi collection is subject to dominant, off-target phenotypic effects Nature Methods, 11, 222-3
Fedele G, et al 2014 An electromagnetic field disrupts negative geotaxis in Drosophila via a CRY-dependent pathway. Nat Comm 5, 4391 doi: 10.1038
Fedele, G., et al 2014 Genetic analysis of circadian responses to low frequency electromagnetic fields in Drosophila melanogaster. PloS Genetics, 10(12):e1004804.
Green EW, et al 2015 Drosophila circadian rhythms in seminatural environments: summer afternoon component is not an artifact and requires TrpA1 channels. Proc Natl Acad Sci USA. 14, 112, 8702-7.





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FTE Category A staff submitted: 37.40

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