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Protein partners of the signalling attenuator Sprouty 2

This project is no longer listed in the FindAPhD
database and may not be available.

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  • Full or part time
    Prof Heath
  • Application Deadline
    Applications accepted all year round

Project Description

Cancer Research UK is the largest supporter of cancer research in British universities and
medical schools and is committed to training the next generation of cancer research
scientists. The PhD Studentships and William Ross PhD Studentships will be available from
1st October 2006. Applications are invited from recent graduates or final year
undergraduates. Applicants should hold or expect to gain a first or upper second class
honours degree.

In 2005 the Cancer Research UK stipend starts at £12,337. Location allowances may also
be provided dependent upon the Host Institution. Please note that Cancer Research UK
does NOT provide overseas university fees.

The aim of this project is determine the biological function(s) of effector proteins in the
activity of the fibroblast growth factor receptor (FGFR) signal attenuator Sprouty 2. The
project will address the following questions:

1: Mapping the interaction between effector proteins and Sprouty 2.

2: Are effectors substrate for Src kinases?

3: Are effectors required for Sprouty mediated attenuation of MAPKinase signalling?

4: Are efffectors required for Sprouty subcellular localisation?

The project will involve molecualr biology, cell biology and protein biochemistry
approaches.

Please find additional funding text below. For further funding details, please see the ‘Funding’ section.
The School of Biosciences offers a number of UK Research Council (e.g. BBSRC, NERC) PhD studentships each year. Fully funded research council studentships are normally only available to UK nationals (or EU nationals resident in the UK) but part-funded studentships may be available to EU applicants resident outside of the UK. The deadline for applications for research council studentships is 31 January each year.

Each year we also have a number of fully funded Darwin Trust Scholarships. These are provided by the Darwin Trust of Edinburgh and are for non-UK students wishing to undertake a PhD in the general area of Molecular Microbiology. The deadline for this scheme is also 31 January each year.

Funding Notes

All applicants should indicate in their applications how they intend to fund their studies. We have a thriving community of international PhD students and encourage applications at any time from students able to find their own funding or who wish to apply for their own funding (e.g. Commonwealth Scholarship, Islamic Development Bank).

The postgraduate funding database provides further information on funding opportunities available http://www.birmingham.ac.uk/postgraduate/funding/FundingFilter.aspx and further information is also available on the School of Biosciences website http://www.birmingham.ac.uk/schools/biosciences/courses/postgraduate/phd.aspx

References

Li X, Brunton VG, Burgar HR, Wheldon LM, Heath JK.
FRS2-dependent SRC activation is required for fibroblast growth factor
receptor-induced phosphorylation of Sprouty and suppression of ERK activity.
J Cell Sci. 2004 Dec 1;117(Pt 25):6007-17.

Li X, Wheldon L, Heath JK.
Sprouty: a controversial role in receptor tyrosine kinase signalling pathways.
Biochem Soc Trans. 2003 Dec;31(Pt 6):1445-6.

How good is research at University of Birmingham in Biological Sciences?

FTE Category A staff submitted: 42.80

Research output data provided by the Research Excellence Framework (REF)

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