Dr Y Wang, Dr R Ewing
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Breast cancer is by far the most common cancer among women in the UK (2013). Mutations in genes such as PTEN are closely correlated with the development of breast cancer, and therefore understanding the molecular consequences of these important mutations will help future development of drugs to restore PTEN function. My group focuses on therapeutic target identification and validation for PTEN-inactive breast cancer, and we have identified the sodium/glucose co-transporter 1 (SGLT1) as a potential therapeutic target in PTEN-inactive breast cancer. We do not yet understand how this protein contributes to the development of breast cancer. This PhD project aims to functionally analyse SGLT1 using state-of-the-art molecular techniques such as combinatorial cloning, genome-wide functional studies, and proteomics. This exciting project will require the student to work at the forefront of basic cancer biology using large-scale “omics” techniques and allowing the student to develop skills in molecular and cellular biology as well as systems and quantitative biological approaches. The successful student will join an active and energetic community of biomedical, biological and bioinformatics researchers at Southampton as well as with the support of scientists in the Francis Crick Institute.
Funding Notes
The project is funded for 4 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. Funding will cover fees and a stipend at current research council rates of £ 14,533 per annum for 201718 entrants.
Due to funding restrictions this position is only open to UK/EU applicants.
References
Applications for Biological Sciences should be submitted online at:
https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=4973&majr=4973&term=201718 Please place Yihua Wang’s name in the field for proposed supervisor.
General enquiries should be made to Dr Yihua Wang at yihua.wang@soton.ac.uk
Any queries on the application process should be made to pgafnes@soton.ac.uk
Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified
The University of Southampton and Biological Sciences both hold an Athena Swan Silver & Bronze Award, respectively, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine. Due consideration will be given to applicants who have taken a career break. University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.
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