Oral and systemic health: unravelling the molecular links between periodontitis and cardiovascular disease

Research Location
The University of Sydney
Primary Supervisor
Prof Joerg Eberhard
Funding
To be discussed
Synopsis
This project aims to establish a mice model of periodontitis where the molecular mechanisms linking oral and cardiovascular health can be unravelled.
Summary
‘Parts of a whole’. Today more than ever science understands the meaning of these words in general health. Every day, more evidences reveal the implications of local responses to environmental challenges (e.g. infections) to the overall equilibrium of the organism’s physiology. For instance, recent findings suggest that local inflammation in the gums – also known as periodontitis – may increase the blocking of blood vessels leading to strokes and death. But how can inflammatory responses in the oral cavity influence cardiovascular and general health? Addressing this unanswered question is the purpose of this project, which has two main goals: i) to establish a mice model of periodontitis, whereby the inflammatory responses in the gum can be produced and replicated successfully, and ii) to unravel the molecular mechanisms linking periodontitis and cardiovascular disease. The outcomes of this project are likely to affect not only basic research, but also clinical preventive care and public health. The student in this project will be exposed to a range of molecular techniques (e.g. PCR, Western Blot), and will have the opportunity to develop their skills on the handling of animal models. The research group is expanding, and there will be a chance for the PhD student to remain as a Postdoctoral Researcher if they wish to continue their research, contingent upon funding availability. The research project is based on the Charles Perkins Centre at the University of Sydney, which is dedicated to easing the global burden of metabolic diseases such as obesity, diabetes, and cardiovascular disease through innovative, interdisciplinary research and teaching. We are looking forward to your insight!
Main project tasks
• Bacteria culture;
• Animal handling (mouse);
• Lab techniques (e.g. ELISA, Western Blot, PCR);
• Writing academically and for popular science;
• Discussion with members of the group;
Requirements
• The applicant must be eligible to apply for a PhD scholarship. The requirements vary from country to country and therefore, the applicant must be aware of the conditions that apply to them. We are willing to support students with their applications.

• Applicants from any background are encouraged to apply.