Applications are invited from Graduates in Chemistry, Pharmacy and Medicinal Chemistry programs to join our group. The project encompasses the synthesis and biological screening of a novel group of new protease inhibitors for the treatment of cancers.
Histone Deacetylase enzymes are zinc dependent metalloproteases which are involved in chromatin remodeling and gene expression by acetyl cleavage from histone lysine residues. It is a promising target for inhibitors as hyper-acetylation leads to cell-cycle arrest and apoptosis in tumor cells. Therefore, our project will involve the following a. combinatorial synthesis of a library of diverse structural silanediol analogues; b. iterative testing of the compound library will be undertaken in-house and international biology partners to elucidate the biological activity and aid the design of more potent analogues. You will undertake the synthesis and in-house testing of these compounds in our world leading facilities, where you will have access to state of the art laboratories and analytical equipment.
You must have, or expect to achieve, at least a 2:1 honours degree or international equivalent. A strong background in chemical synthesis, with a knowledge of microbiological techniques and protein purification being advantageous.
This award is available to UK/EU and international applicants. If English is not your first language, you must have IELTS 7 with at least 6.5 in the written component, or equivalent.
How to apply
Please send a CV and covering letter to Elizabeth Amies ([email protected]). The covering letter must state the title of the studentship, quote the studentship reference code PH005 and state how your interests and experience relate to the project.