• University of Bristol Featured PhD Programmes
  • National University of Singapore Featured PhD Programmes
  • Northumbria University Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of East Anglia Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • Medical Research Council, Harwell Featured PhD Programmes

Postgrad LIVE! Study Fair

Birmingham | Bristol | Sheffield | Liverpool | Edinburgh

Imperial College London Featured PhD Programmes
University of the West of England, Bristol Featured PhD Programmes
University of Glasgow Featured PhD Programmes
Loughborough University London Featured PhD Programmes
University of Southampton Featured PhD Programmes

PhD studentship in Medicinal Chemistry - ‘Development of novel Silanediol HDAC inhibitors for the treatment of cancer’

  • Full or part time
    Dr J D Sellars
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Applications are invited from Graduates in Chemistry, Pharmacy and Medicinal Chemistry programs to join our group. The project encompasses the synthesis and biological screening of a novel group of new protease inhibitors for the treatment of cancers.

Histone Deacetylase enzymes are zinc dependent metalloproteases which are involved in chromatin remodeling and gene expression by acetyl cleavage from histone lysine residues. It is a promising target for inhibitors as hyper-acetylation leads to cell-cycle arrest and apoptosis in tumor cells. Therefore, our project will involve the following a. combinatorial synthesis of a library of diverse structural silanediol analogues; b. iterative testing of the compound library will be undertaken in-house and international biology partners to elucidate the biological activity and aid the design of more potent analogues. You will undertake the synthesis and in-house testing of these compounds in our world leading facilities, where you will have access to state of the art laboratories and analytical equipment.

Eligibility Criteria

You must have, or expect to achieve, at least a 2:1 honours degree or international equivalent. A strong background in chemical synthesis, with a knowledge of microbiological techniques and protein purification being advantageous.

This award is available to UK/EU and international applicants. If English is not your first language, you must have IELTS 7 with at least 6.5 in the written component, or equivalent.

How to apply

Please send a CV and covering letter to Elizabeth Amies (). The covering letter must state the title of the studentship, quote the studentship reference code PH005 and state how your interests and experience relate to the project.


For further details, please contact:
Miss E Amies

Funding Notes

Start Date: January 2018

The funding will need to cover a 3 year PhD

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully

Meet Newcastle University at


Cookie Policy    X