Investigating the role of protein homeostasis in dementia at University of Sheffield on FindAPhD.com

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Prof Kurt de Vos, Dr Andy Grierson No more applications being accepted Funded PhD Project (European/UK Students Only)

About the Project

Applications are now being invited for a three-year Basic Science PhD Studentship funded by Alzheimer’s Society, starting in October 2017. The successful candidate will join an established training programme at the Sheffield Institute for Translational neuroscience (SITraN) in the group of Dr Kurt De Vos.

Expansions of a noncoding GGGGCC hexanucleotide repeat in the C9ORF72 gene are the most common genetic defect found to date in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). How the repeat expansion causes disease is not known, but appears to involve both loss-of-function (C9ORF72 haploinsufficiency), and gain-of-function (repeat-associated non-ATG (RAN) translation, RNA toxicity) mechanisms. To unravel the ways in which C9orf72 expansions cause disease it is crucial to understand the normal functions of the C9orf72 protein.
In this project we will investigate how the cellular levels of C9orf72 are regulated and leverage this knowledge to devise novel therapeutic strategies.

Funding Notes

A grant from Alzheimer’s Society covers fees and stipend at Home/EU level. Overseas students may apply but will need to fund the difference in fees between Home and Overseas rate from another source.

Entry Requirements:
Candidates must have a first or upper second class honors degree or significant research experience.

How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select 'Neuroscience' as the department.

References

Where will I study?

University of Sheffield

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Investigating the role of protein homeostasis in dementia

University of Sheffield Department of Neuroscience