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  PhD position in computational epigenetics and non-coding RNA analysis


   Division of Molecular Embryology

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  Prof C Niehrs  No more applications being accepted  Funded PhD Project (European/UK Students Only)

About the Project

Project Description:
The Institute of Molecular Biology gGmbH (IMB) is a Centre of Excellence for Life Sciences, funded by the Boehringer Ingelheim Foundation. It is located within the campus of the Johannes Gutenberg-University, Mainz, Germany.

Applications are invited for a PhD positions to study the role of long non-coding RNAs in the regulation of DNA demethylation in embryonic stem cells in the research group of Professor Christof Niehrs. See also www.imb-mainz.de/research-at-imb/niehrs/research/

Project
· Analysis of RNA-seq, ChIP-seq, DNA methylome datasets using own and in-house provided pipelines
· Computational Analysis of non-coding RNA structure
· Integrate quantitative data from multiple omics sources
· Perform personalized post-quantitation analysis (e.g. GSEA, comparison to published datasets)
· Support lab members with your bioinformatics skills

You have
· Masters in Bioinformatics, Computational Biology, Natural Sciences or related areas
· Sound experience in R scripting or Python
· Familiarity with large scale data analysis (RNA-seq, ChIP-seq and related)
· Excellent communication skills and good team spirit with the ability to solve problems independently
· Fluent in English (spoken and written)

We offer
• An international and vibrant working environment
• Competitive stipend
• Training opportunities


Starting date: by November 2018

Duration: Initially 3 years; option for further extension

To apply please send a single PDF file containing your cover letter stating research and career interests, CV, scans of your degrees (Germans: including copies of Abitur- & Diplom/Master Zeugnis), and contact details of 2 references to [Email Address Removed].

Closing date: 30 June 2018


References

Arab, K., et al. (2014). Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. Mol. Cell. 55, 604-614.

 About the Project