Prof Eamonn Gaffney, Prof Holm Uhlig
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Humans and animals have a complex relationship between the host and their intestinal microbiota that is required to maintain long lived healthy living. We and others have developed multi-scale agent based models of the mouse intestine to study both bacterial and immune cell dynamics.
The development of next generation sequencing has provided vast amounts of genomic and transcriptomics data on human microbiota and intestinal immune cells; however integrating these different types and scales of datasets into a mechanistic understanding of gut physiology is a challenge. We have previously utilised machine learning to identify key pathways and molecules regulating intestinal immune function.
Through combining advanced machine learning based approaches with multiscale computational models, the project will aim to develop a model of the human intestinal microenvironment. This will be in collaboration with, and utilising virtual laboratories technology developed by, Simomics Ltd, and will also aim to test the modelling framework through comparison to transcriptomics datasets from monogenic human deletions which lead to intestinal dysbiosis.
Funding Notes
This project is funded for four years by the Biotechnology and Biological Sciences Research Council BBSRC. BBSRC eligibility criteria apply (http://www.bbsrc.ac.uk/documents/studentship-eligibilitypdf/). EU nationals who do not meet BBSRC residence criteria are encouraged to contact the programme administrator to check their eligibility for BBSRC funding before submitting a formal application. Successful students will receive a stipend of no less than the standard RCUK stipend rate, currently set at £14,553 per year, which will usually be supplemented by the industrial partner.
To apply: http://www.biodtp.ox.ac.uk/how-to-apply/index.html
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