Synthesis and Evaluation of Novel PET Probes for Imaging Aggregated Protein Structures linked with Neurodegenerative Diseases

This project’s objective is to develop novel in vivo PET probes that are selective to protein aggregates, which are neuropathological features of various neurodegenerative diseases, including Alzheimer’s disease and frontotemperal dementia. The project would involve organic synthesis and in vitro assays of compounds, combined with developing the radiosynthesis of the novel PET probes. Evaluation of the probes would involve in vitro radiographic methods and in vivo imaging in models of dementia using a high resolution PET scanner.