Role of nuclear architecture in the control of the timing of activation of origins of DNA replication

Interested individuals must follow Steps 1, 2 and 3 at this link on how to apply
http://www.ed.ac.uk/biology/prospective-students/postgraduate/pgr/how-to-apply

DNA replication is a key event for the transmission of genetic information. The eukaryotic genome does not replicate all at once, but it follows a temporal program that reproducibly ensures replication of different parts of the genome at different stages of S-phase. This is called the DNA replication-timing program. There are many circumstantial evidences connecting re-organization of nuclear architecture after mitosis and the establishment of the order of activation of origins of DNA replication. However, there is no proof that the latter depends on the former. In this project, we will examine the role of several structural nuclear proteins in the determination of the replication timing program, employing advanced genetic manipulation of stem cells, protein engineering and genome-wide sequencing. The aim of the project is to resolve the long-standing question of the molecular machinery linking nuclear architecture and the timing of DNA replication.

If you are interested in cell cycle, DNA replication, nuclear organization and want to work with mammalian primary and stem cells join our group. We are looking for enthusiastic, flexible and hard-working candidates driven by curiosity and passion for science. Basic knowledge of cell/molecular biology and ability to work in English, in an international environment are required