Dr D Odom
No more applications being accepted
Funded PhD Project (Students Worldwide)
About the Project
Recent studies in the Odom laboratory have revealed that older animals have substantially increased cell-to-cell transcriptional variability when compared to genetically identical younger mice (Martinez et al Science 2017). The goal of this PhD project is to establish and test the mechanisms that cause this increase in transcriptional variability during ageing. Mapping the active enhancers, promoters, and transcription in purified populations of cells from younger and older animals will allow differences in regulatory activity to be quantified. Candidate regulatory regions will then be tested for function by creating genetically engineered mouse models. There is also the possibility of pursuing a comparative functional genomics approach in the same purified cell type in different species, to evaluate how conserved or divergent the mechanisms underlying ageing are.
Excellent academic training in modern genetics and genomics is a prerequisite. A research master’s degree, as well as good familiarity with commonly-used experimental genomics techniques such as RNA-seq and ChIP-seq would be highly desirable. Prior experience with single cell technologies, such as Fluidigm or Drop-seq systems would be advantageous but not necessary.
Funding Notes
This studentship is funded by Cancer Research UK and includes full funding for University and College fees and in addition, a stipend of £19,000 per annum, initially for 3 years, with funding for a further year possible as required.
No nationality restrictions apply to this Cancer Research UK funded studentship. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.
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