Understanding the important role of LRRK2 protein kinase in Parkinson’s disease

This project aims to build on recent progress that our laboratory has made that has identified a group of Rab GTPase proteins as the key physiological targets of LRRK2 (PMID:27474410 and 26824392). The goal of this PhD project would be to build on these findings to learn more about how LRRK2 is regulated and functions and how mutations in these pathways are linked to Parkinson’s disease. Knowledge from this research could lead to new strategies to better diagnose and treat Parkinson’s disease.

At the MRC PPU, we offer the possibility of two 4.5 month rotations in labs of their choice – a range of other projects from MRC PPU scientists are advertised on this website. Rotations provide valuable experience and help with deciding on the choice of PhD project and research group. Alternatively, students can opt out of rotations and go to just one lab for a PhD.

Please send a CV with contact details of three referees to and a cover letter explaining why you have chosen to apply to MRC PPU to [Email Address Removed]..uk. The closing date for applications is March 31st, with interviews at the end of April.