• University of Birmingham Featured PhD Programmes
  • Northumbria University Featured PhD Programmes
  • University of Stirling Featured PhD Programmes
  • University of Warwick Featured PhD Programmes
  • Queen’s University Belfast Featured PhD Programmes
  • University of Manchester Featured PhD Programmes
  • FindA University Ltd Featured PhD Programmes
  • University of Macau Featured PhD Programmes
University College London Featured PhD Programmes
ESPCI Paris Tech Featured PhD Programmes
University of Southampton Featured PhD Programmes
University of West London Featured PhD Programmes
Newcastle University Featured PhD Programmes

Elucidating the signalling pathways important for plasma cell biology and antibody secretion

Project Description

Plasma cells are the antibody secreting cells of the immune system thus are vital for fighting infection. However, dysregulation of plasma cell function is linked to a broad range of disease from Lupus to multiple myeloma. At present, it is not known how plasma cell differentiation and homeostasis is regulated. The aim of this PhD project is to identify the key signaling pathways critical for this process. To identify these pathways we will use a combination of cutting edge in vitro cell culture models and novel mass-spectrometry based approaches. Once key pathways have been identified, we will manipulate them using chemical and genetic based approaches and determine how this affects plasma cell biology. In the long term, this information may help in the development of novel drugs for regulating plasma cell function in vivo. This project represents an exciting training opportunity where the student will become an expert in advanced proteomics, mechanistic cell biology and immunology.

Science Graduate School
As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience the breadth of technologies that are used in academia, industry and many related careers. Visit http://www.sheffield.ac.uk/sgs to learn more.

Funding Notes

Self funded students only.

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully

Cookie Policy    X