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  Investigating the role of undecaprenyl metabolism in the biogenesis of the outer membrane of Escherichia coli


   School of Clinical & Applied Sciences

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  Dr J George, Prof G Jones  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

A project aimed at investigating the control of undecaprenyl metabolism in the biogenesis of the E. coli cell envelope is available at the Centre for Biomedical Science Research, Leeds Beckett University. Undecaprenyl is an essential carrier for multiple bacterial cell wall components such as peptidoglycan, lipopolysaccharide (LPS) and surface antigens. However, the regulatory processes underpinning both the synthesis and recycling of this molecule are poorly understood. This project will use both traditional biochemical and microbiology methods coupled with cutting-edge computational modelling techniques, to probe the biological importance of each of these mechanisms. A greater understanding of this molecular pathway will allow the design of new antimicrobial strategies to combat bacterial infection and disease.

The criteria listed below will be used in selecting those applicants who will be called for interview and those who will be successful in securing a PhD Studentship

Candidates require a 1st or upper 2nd class B.Sc honours degree in either biochemistry, microbiology or a related subject
a strong interest in computational biology and its application to drug discovery, will be an advantage
This PhD is funded by Oppilotech Ltd [www.oppilotech.com] and Leeds Beckett University, and provides a stipend of £14,553 pa and covers PhD fees for a three-year period. The studentship is available with a February 1st 2018 start date.

Applicants should apply through Leeds Beckett graduate school: [Email Address Removed].

Applicants should submit the following:

A completed application form and a full CV
Copy of Photo page from passport
Certificates and transcripts
Proof of English (for EU/international applicants only IELTS, PEIRSONS OR TOEFL
Certificates and transcripts
Ensure all sections of the application are completed
Photo page from passport received

Closing date for applications is Sunday 3rd December 2017.

For further information about the project please contact Dr. John George or Professor Gary Jones.

****Closing date for applications midnight, Sunday 3rd December 2017****

 About the Project