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Development of nanomaterials as Magnetic Resonance Imaging (MRI) Contrast agents (using Organic Chemistry, Chemical Biology and Materials Science)


Project Description

A fully funded 3-year PhD studentship is available in UCL Chemistry to work on a highly interdisciplinary project in the groups of Dr Vijay Chudasama (60%) and Dr Gemma-Louise Davies (40%). The project will involve: (i) the synthesis of small molecules and their application in the site-selective modification of proteins, (ii) the development of nanostructured materials as Magnetic Resonance Imaging (MRI) contrast agents, and (iii) the controlled attachment of the site-selectively modified proteins onto the surface of the nanostructured material. The aim is to target the MRI contrast agents to specific disease targets using state-of-the-art bioconjugation chemistry. The student will gain expertise in synthetic organic chemistry, bioconjugation, inorganic nanoparticle synthetic techniques, and the use of a variety of analytical techniques, including, but not limited to, mass spectrometry, ELISAs, SPR, relaxometry, clinical MRI and electron microscopy.

Please visit our group websites for more details about our research: http://chudasama-group.eu/ and https://gemmalouisedavies.com/

The applicants should have, or expect to gain, at least a 2.1 honours or equivalent at Masters level in Chemistry, or a related discipline. The successful applicant will demonstrate strong interest and self-motivation in the subject and the ability to think analytically and creatively. An enquiring and rigorous approach to research as well as good team-working, observational and communication skills (both presentation and writing skills in English) are also essential. Previous research experience in contributing to a collaborative interdisciplinary research environment is highly desirable but not essential, as training will be provided. UCL offers a world leading scientific environment in the heart of London.

Applicants should send their applications (motivation letter, CV and contact info for 2 referees) by email to Dr Chudasama (), who may also be approached for informal enquiries.

Suitable candidates will be required to complete an electronic application form at http://www.ucl.ac.uk/prospective-students/graduate/apply. Any admissions queries should be directed to .

Funding Notes

Due to funding restrictions, only UK/EU students who meet the 3 years residency criteria are eligible for this studentship. The start date for the PhD is in late September 2018. The deadline for applications is 8th January 2018, with interviews to be held in February, but the position will be filled as soon as an appropriate candidate is found.

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