How does the plant regulate receptor signaling to balance immune response and growth? (MENKES18DTPR)

Plants sense microbial pathogens through the detection of pathogen associated molecular patterns (PAMP) and this is mediated by cell surface localized pattern recognition receptors (PRR). Perception of PAMPs triggers a signaling network that includes activation of mitogen activated protein kinases (MAPK), activation of defense gene expression and ultimately leads to PAMP triggered immunity (PTI). Perception of PAMPs also leads to growth inhibition, by mostly unknown signaling events. Since the regulation of growth also involves receptor-mediated perception of plant peptides there is potential for cross regulation. Some connections have already been identified that suggest some of the signaling components are shared between PRR signaling and plant peptide signaling, such as co-receptor BAK1 (1). Furthermore, perception of plant peptides has recently also been linked to negative regulation of defense response and suppresses resistance to microbial pathogens (2,3). The current project investigates the links between PRR signaling and plant peptide signaling controlling growth. In the current project the receptor based signaling event will be studied with advanced proteomics approaches and cell biology (using confocal microscopy). The project will also involve molecular biology and protein biochemistry allowing for a broad training of the candidate. Further information can be found at http://www.tsl.ac.uk/groups/proteomics/ or by contacting [Email Address Removed].

The Norwich Biosciences Doctoral Training Partnership (NRPDTP) offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply.

For further information and to apply, please visit our website: http://www.biodtp.norwichresearchpark.ac.uk

Please note, this project is directly funded and will be shortlisted and interviewed separately to the main Norwich Research Park DTP Programme.