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DiMeN Doctoral Training Partnership: Identifying and testing therapeutic targets for boosting immune-directed senescent cell clearance and promote healthy ageing using the zebrafish model

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  • Full or part time
    Dr C Henriques
    Prof I Bellantuono
    Dr K Whysall
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

The number of people over the age of 65 is predicted to double within the next 50 years, accompanied by an increase in chronic-diseases, which already consume up to 80% of health-care costs. Developing therapies for chronic ageing-diseases is, therefore, an urgent priority.
A fundamental feature underlying diseases of ageing is impaired tissue-homeostasis, driven by telomere shortening and consequent replicative cell senescence. There is strong evidence implicating telomere dysfunction and senescence in age- associated pathologies, such as atherosclerosis and cancer. Encouragingly, removing aberrantly accumulated senescent cells can significantly ameliorate ageing phenotypes in mice, highlighting senescence as an important therapeutic target.
In young tissue, immune-surveillance clears senescence. With ageing however, senescent cells accumulate, causing disease. Yet the mechanisms regulating senescent cell clearance in ageing, particularly telomere-dependent replicative senescence, are unknown, limiting our ability to harness its therapeutic potential.
This project aims at determining the key mechanisms regulating immune-directed clearance of senescent cells in ageing, using the zebrafish model, with the aim of identifying potential therapeutic targets for improving tissue health in the old.

This is a project that offers excellent training across the disciplines of ageing, telomere biology, immunology and tissue regeneration.

Funding Notes

This studentship is part of the MRC Discovery Medicine North (DiMeN) partnership and is funded for 3.5 years. Including the following financial support:
Tax-free maintenance grant at the national UK Research Council rate
Full payment of tuition fees at the standard UK/EU rate
Research training support grant (RTSG)
Travel allowance for attendance at UK and international meetings
Opportunity to apply for Flexible Funds for further training and development
Please carefully read eligibility requirements and how to apply on our website, then use the link on this page to submit an application: https://goo.gl/jvPe1N


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