This studentship is part of the MRC Discovery Medicine North (DiMeN) partnership and is funded for 3.5 years. Including the following financial support:
Tax-free maintenance grant at the national UK Research Council rate
Full payment of tuition fees at the standard UK/EU rate
Research training support grant (RTSG)
Travel allowance for attendance at UK and international meetings
Opportunity to apply for Flexible Funds for further training and development
Please carefully read eligibility requirements and how to apply on our website, then use the link on this page to submit an application: View Website
Buskin et al. (2017) Alternative splicing of mRNA processing genes underlines the retinal specific phenotype of retinitis pigmentosa caused by mutations in the PRPF31 gene. Under review (Cell Stem Cell).
Megaw E, Abu-Arafeh H, Mellough C, Gurniak-Witke C, Witke W, Dhillon B, Wright AF, Lako M and Ffrench-Constant C. Human induced pluripotent stem cell and animal models of Xlinked retinitis pigmentosa identify impaired gelsolin activation as a cause of photoreceptor loss. Nature Communications Aug 16;8(1):271. doi: 10.1038/s41467-017-00111-8.
Hallam D, Collin J, Bojic S, Chichagova V, Buskin A, Yu X, Lafage, L, Otten G, Anyfantis G, Mellough C, Przyborski S, Alharthi S, Korolchuk V, Lotery A, Saretzki G, McKibbin M, Armstrong L, Steel D, Kavanagh D and Lako M. An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure. Stem Cells 2017, in press.
Chichagova V, Hallam D, Collin J, Buskin A, Saretzki G, Armstrong L, Yu-Man P, Lako M and Steel D. Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring m.3243A>G mitochondrial DNA mutation. Scientific Reports 2017, in press.
Wheway G et al. (2015). An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nature Cell Biology 17: 1074-87.
Lambacher NJ et al. (2016). TMEM107 recruits ciliopathy proteins to anchored periodic subdomains of the ciliary transition zone membrane and is mutated in Joubert syndrome. Nature Cell Biology 18:122-31.
Malicki J & Johnson CA (2017). The cilium: cellular antenna and central processing unit. Trends in Cell Biology 27:126-140.