Design, Chemical Synthesis and Evaluation of Nucleoside Analogues

All viruses, irrespective of the disease they cause, have to replicate in order to survive. Drugs that block viral RNA or DNA replication by mimicking the natural building blocks of RNA and DNA (A, C, G, T/U) are known as nucleoside analogues. There are three distinct features of nucleosides that make them the preferred treatment for an infectious disease where a nucleoside is available: high barrier to resistance,broad spectrum of activity and high efficacy. This can be observed in the treatments of HSV (Aciclovir and Ganciclovir), HIV (Tenofovir, Zidovudine, Abacavir Emtricitabine and Lamivudine), HBV (Entecavir, Tenofovi, Adefovir, Lamivudine and Telbivudine) and HCV (Sofosbuvir).

Your PhD project will involve the design and chemical synthesis of a new class of nucleoside analogue, focusing on mimetic modifications to the ribose ring. You will also be involved in applying the mimetic nucleoside within the synthesis of current anti-viral drugs. You will receive training in organic synthesis, carbohydrate chemistry and medicinal chemistry. Transferable skills such as reporting of results orally and in writing, time management, project planning and management will be also developed.

Please quote FNS GS 2017-24 on your application.