Role of the Immune System in Venous Thrombosis

A PhD project with Dr. A. Brill will focus on studying the function of various aspects of the immune system involvement in deep vein thrombosis (DVT). DVT is development of blood clots in deep veins, predominantly (but not exclusively) in the legs. Current approaches for DVT prophylaxis are largely based on targeting coagulation factors, which inevitably results in bleeding complication in a part of patients. Our aim is to identify alternative targets that would not be implicated in normal hemostasis and would not therefore cause excessive bleeding. As DVT has recently been shown to be an “immunothrombosis”, different components of the immune system would be obvious candidates. We have recently demonstrated a key role of mast cells in DVT and the present project will be a logical continuation of this line of research. The research is planned to be fully translational, i.e., we use in vivo models of DVT, intravital microscopy and other similar techniques as well as have approach to material from patients to make sure that our findings are relevant for a real clinical situation.

Applications are invited for a 3-year PhD Studentship starting in summer/fall 2018 for a self-funded student

Person Specification

Applicants should have a strong background in thrombosis, vascular biology, immunology (especially the innate immune system) and inflammation. A strong experience with in vivo work is required. An experience with biochemical methods (e.g., Western blotting, immunoprecipitation), cell culture, isolation of blood cells, histological methods (preparation and sectioning of paraffin and frozen blocks, immunostaining) and microscopy is expected. We are looking for a highly motivated student, ready to work hard and oriented on high ranked publications as a result of his/her studies.

How to apply

Informal enquiries should be directed to Dr.A.Brill, Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom. e-mail: [Email Address Removed]

Applications should be directed to David Piela ([Email Address Removed]). To apply, please send:

• A detailed CV, including your nationality and country of birth;
• Names and addresses of two referees;
• A covering letter highlighting your research experience/capabilities;
• Copies of your degree certificates with transcripts;
• Evidence of your proficiency in the English language, if applicable.