About the Project
Ultrafast spectroscopy is the only route to measuring real time molecular dynamics. In recent experiments we have revealed the fast functional dynamics associated with protein function and the structure changes which underlie the operation of molecular motors.
In this PhD project you will apply ultrafast lasers generating sub 100 fs pulses from the IR to the UV to measure excited state processes in samples relevant to both nanomachines and photobiology. Recent projects include studies of green fluorescent protein dynamics, molecular motor photophysics and dynamics in complex fluids. The group is well funded with three ultrafast laser systems and a variety of support apparatus and maintains a number of national and international collaborations. The student will join an active friendly dynamic research group and become expert in ultrafast lasers, instrument development, spectroscopy and data analysis.
For more information on the supervisor for this project, please go here: http://www.uea.ac.uk/chemistry/people/profile/s-meech
Project start date: 2018
Mode of study: Full time
Entry requirements: Acceptable first degree Chemistry, Physics or related. The standard minimum entry requirement is 2:1
Application deadline: 31 May 2018, please note applications are processed as soon as they are received and the project may be filled before the closing date, so early application is encouraged.
Funding Notes
This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at http://www.uea.ac.uk/study/postgraduate/research-degrees/fees-and-funding.
A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.
References
i) S. P. Laptenok, J. Conyard, P. C. Bulman Page, Y. Chan, M. You, S. R. Jaffrey and Stephen R. Meech ‘Ultrafast Photoacid Behaviour in a Fluorinated Green Fluorescent Protein Chromophore’ Chemical Science Chemical Science, 2016, 7, 5747 – 5752
ii) S. P. Laptenok, A. Lukacs, R. Brust, A. Gil, I. Sazanovich, G. M. Greetham, P. J. Tonge and S. R. Meech ‘Complete Proton Transfer Cycle in GFP and Its T203V and S205V Mutants’ Angewante Chemie, 2016, 138, 926-935
iii) F. Palombo, I. Heisler, B. Hribar-Lee, S. R. Meech ‘Tuning the Hydrophobic Interaction: Ultrafast Optical Kerr Effect Study of Aqueous Ionene Solutions’ J. Phys. Chem. B 2015, 119, 8900 - 8908
iv) J. Conyard, A. Cnossen, W. R. Brown, B. L. Feringa, and S. R. Meech ‘Chemically Optimising Operational Efficiency of Molecular Rotary Motors’ J. Amer. Chem. Soc. 2014, 136, 9692-9700
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