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Systems Biology of receptor signaling

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database and may not be available.

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  • Full or part time
    Prof Heath
  • Application Deadline
    Applications accepted all year round

Project Description

The laboratory studies the structure and function of molecules involved in
transmembrane receptor signalling by cytokines and growth factors. Aberrant regulation
of receptor signaling underlies many common human pathologies including cancer,
inflammation, tissue repair and infertility.

Our current preoccupation is defining the topology of receptor response networks in
normal and malignant cells to identify the key determinants of signaling dynamics.

The research involves a range of techniques including proteomics, bioinformatics and
computational biology, molecular biology and genetics.

Please find additional funding text below. For further funding details, please see the ‘Funding’ section.
The School of Biosciences offers a number of UK Research Council (e.g. BBSRC, NERC) PhD studentships each year. Fully funded research council studentships are normally only available to UK nationals (or EU nationals resident in the UK) but part-funded studentships may be available to EU applicants resident outside of the UK. The deadline for applications for research council studentships is 31 January each year.

Each year we also have a number of fully funded Darwin Trust Scholarships. These are provided by the Darwin Trust of Edinburgh and are for non-UK students wishing to undertake a PhD in the general area of Molecular Microbiology. The deadline for this scheme is also 31 January each year.

Funding Notes

All applicants should indicate in their applications how they intend to fund their studies. We have a thriving community of international PhD students and encourage applications at any time from students able to find their own funding or who wish to apply for their own funding (e.g. Commonwealth Scholarship, Islamic Development Bank).

The postgraduate funding database provides further information on funding opportunities available http://www.birmingham.ac.uk/postgraduate/funding/FundingFilter.aspx and further information is also available on the School of Biosciences website http://www.birmingham.ac.uk/schools/biosciences/courses/postgraduate/phd.aspx


References

Bryan P. Haines, Lee M. Wheldon, Dennis Summerbell, John K. Heath and Peter W. J. Rigby (2006) "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development." Dev Biol. 2006 Sep 1;297(1):14-25. Epub 2006 Apr 21.

Heath, J.K., Kwiatkwoska M.Z., Norman G., Parker, D., and Tymyschyn O (2006) Applying probabilistic model checking to the analysis of biological systems. Computational methods in Systems Biology volume 4210 of Lecture Notes in Bioinformatics, pages 32-47, Springer Verlag.

Marta Kwiatkowska, Gethin Norman, David Parker, Oksana Tymchyshyn, John Heath, Eamonn Gaffney (2006). Simulation and verification for computational modelling of signaling pathways Proceeding of the Winter simulation symposium on modelling and simulation in Systems Biology 1666-1674.

Underhill-day. N and Heath JK (2006) Private and public gp130 family receptor signaling pathways dictate the pleiotropic responses of breast tumour cells to Oncostatin M: characterisation of the OSMRb –specific kernel. Cancer Res. 2006 Nov 15;66(22):10891-901.

Matadeen R, Hon W-C, Heath JK, Jones EY, Fuller SD (2007) The mechanism of Trans-Membrane Communication in a gp130 – Receptor Complex revealed by cryo-electron microscopy. Structure 5(4):441-8.

Sandilands E, Akbazardeh S, McEwan D, Frame M and Heath JK (2007) Src kinase dictates the activation, trafficking and signalling dynamics of Fibroblast Growth Factor Receptors. EMBO Reports 8: 1162-1169

Vecchione A, Cooper HJ, Trim KJ, Wheldon L and Heath, JK (2007) Protein partners in the life history of activated fibroblast growth factor receptors. Proteomics Nov 19th 2007 Epub ahead of print

Heath JK, Kwiatkowska, MZ, Norman G, Parker D and Tymychyn O (2007) Probabilistic model checking of complex biological pathways. Theoretical computer science in press

Guerrio ML, Heath JK and Priami C (2007) An automated translation from a narrative language for biological modelling into process algebra. Computational Methods in Systems Biology 4695 136-151

How good is research at University of Birmingham in Biological Sciences?

FTE Category A staff submitted: 42.80

Research output data provided by the Research Excellence Framework (REF)

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