About the Project
The Macias lab at IRB Barcelona is searching for a highly motivated PhD student of Structural Biology, to join our laboratory. Our research interest is focused on deciphering the mechanisms that correlate cell signaling with gene expression using high resolution structural biology. We also aim at discovering how these mechanisms are regulated, and their consequent implications in human diseases from the structural point of view. Recently, our work has been focused on the family of transcription factors Smads, where we have discovered a mechanism that labels these key components of the TGF-beta pathway first for activation and then for degradation. We have also identified new DNA binding sites specifically recognized by Smad proteins.
Using NMR and X-ray crystallography we are currently characterizing the interactions of Smad proteins and cofactors with DNA promoters, to provide a first understanding of how these molecular machines work and to pave the basis for the design of small molecular inhibitors specifically targeted towards tumor-derived Smad forms.
More information about us:
https://www.irbbarcelona.org/en/profile/maria-j-macias
http://maciasnmr.net/
Full information for the application and the call are provided at http://bist.eu/prebist/
Interested candidates in our project should send a CV, and academic grades to [Email Address Removed]
Granted fellowships are for 4 years and include:
• Annual gross salary: 26.519,19€ plus a single payment of 1504,89 relocation support (Spanish tax and social security deductions apply),
• Close mentoring and supervision through prestigious Researchers,
• A personalized doctoral career development plan,
• A training program for scientific and transferable skills.
Deadline: 31 May 2018
Interviews: from 12 to 27 July 2018
Incorporation foreseen around 09/2018
Eligibility criteria
• Having not spent more than 12 months of the prior 36 months in Spain, at the time of the call deadline. You will be required to confirm your compliance through a self-declaration.
• Hold a University degree (by the time of enrollment in the PhD program) that would qualify the applicant to enter one of the PhD programmes recognized by the BIST research centers. These have formal agreements with the major Catalan Universities (UB, UAB, UPC, URV, and UPF) whereby BIST senior researchers (generally of professorial rank and enjoying international recognition) are accredited to supervise PhD students, who do their research at BIST research centres and obtain their degree from the corresponding university. Please provide evidence when you apply (e.g. scanned copy of your degree or similar).
• At the time of the call deadline, be in the first 4 years of your scientific post gradual career (full-time equivalent research experience). In case your University degree was longer ago than 4 years, you will need to provide documental evidence for complying with these criteria.
• Having not been awarded yet a PhD degree.
Selection process
The evaluation of eligible candidates will be carried out by an external, independent selection panel. The evaluation will be objective, independent, free of conflicts of interest and the selection will be based on merits, equal opportunities and freedom of choice of research.
The review procedure will be carried out in various steps:
1. First review by the selection panel reviewing the documentation submitted with the application. General suitability and admissibility for the PREBIST programme will be evaluated (review 1).
2. Second review by the selection panel: interviews (review 2).
3. Decision on awardees, reserve list and rejected candidatures.
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