Dr K Rouault-Pierre
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
We are pleased to offer the below fully funded studentship, starting in September 2018.
Our Institute has an international reputation for cancer research, with world renowned experts in the field. Our PhD training programme aims to develop a cohort of scientists equipped both intellectually and technically to conduct the highest quality research on cancer.
Our research degrees are supplemented by a comprehensive support programme, providing training in a wide range of biomedical laboratory methods and other vital transferable skills.
You will be based at the beautiful Charterhouse Square campus in the heart of London.
Project Outline:
The successful candidate undertake molecular and phenotypic investigations in the crosstalk between stroma cells and haematopoietic malignant cells within a Stress integration in normal and malignant haematopoietic cells laboratory. This is a multidisciplinary centre that includes wet lab scientists and clinicians.
The prevalence of somatic mutations increases with age, leading to clonal haematopoiesis that see the emergence of Clonal Haematopoiesis of Indeterminate Potential (CHIP). 30% of Acute Myeloid Leukaemia (AML) with normal karyotype and 8-10% Myelodysplastic Syndromes (MDS) harbour mutations in the DNMT3A gene, and these mutations are assumed to be an early event in leukaemogenesis. However, how clonal selection occurs is still to be determined. Here we want to shed light on the role of the stroma cells in driving clonal evolution and selection. Multiparametric flow cytometry analysis and the use of different omics tool will be used to get down to the single cell resolution necessary to understand clonal architecture and evolution. Therefore we are seeking a motivated PhD student to investigate the role of stroma components in driving clonal fitness, in primary Acute Myeloid Leukaemia and Myelodysplastic Syndromes samples.
Applicants should have a strong background in the relevant biological subjects (with a significant component of molecular analysis and cell culture). Research experience in primary human cells culture, molecular biology and cloning techniques, use of lentivirus reporters, flow cytometry would be an advantage. A demonstrated ability to communicate well, to be enthusiastic about science, work within a team and maintain good laboratory records are also essential.
Informal enquiries about this post, including arrangements to visit the Institute/Centre, can be made to Dr. Rouault-Pierre, Tel: 0044+ (0)20 7882 8814 or email [Email Address Removed].
For more information, please see our website:
https://www.bci.qmul.ac.uk/en/study-with-us/postgraduate-research/bci-funded-phd-studentships-6-positions
Funding Notes
The studentship includes the following funding for 3 years:
- A tax free annual stipend of £21,000
- Tuition Fees at the Home/EU rate*
- Project consumables
*If you are considered an overseas student for fee purposes, you are welcome to apply for these studentships, however you will be required to cover the difference in tuition fees.
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