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Dr M Paget
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
An industrial BBSRC CASE studentship is available in the research group of Dr Mark Paget, in partnership with TMO Renewables Ltd (Surrey Research Park, Guildford, UK).
There is a pressing need to develop “second generation” biofuel technologies that efficiently utilise recalcitrant waste materials. One bacterium that has been commercially developed by TMO Renewables is the thermophile Geobacillus thermoglucosidasius, which can produce ethanol from solid municipal waste. This project aims to elucidate the regulatory networks and control mechanisms that modulate fermentative gene expression in response to redox change in G. thermoglucosidasius. The student will apply genome-wide techniques such as CHIP-seq to identify regulons, together with biochemical approaches to characterise specific regulators. As well as improving our fundamental understanding of redox control of gene expression in bacteria, this project should yield new possibilities for the development of new industrially important strains and tools.
The successful candidate will be a dynamic and motivated individual with a relevant academic background (e.g. Biochemistry). The student will be based at the University of Sussex, but interact closely with scientists at TMO Renewables, including extended research visits.
There is a pressing need to develop “second generation” biofuel technologies that efficiently utilise recalcitrant waste materials. One bacterium that has been commercially developed by TMO Renewables is the thermophile Geobacillus thermoglucosidasius, which can produce ethanol from solid municipal waste. This project aims to elucidate the regulatory networks and control mechanisms that modulate fermentative gene expression in response to redox change in G. thermoglucosidasius. The student will apply genome-wide techniques such as CHIP-seq to identify regulons, together with biochemical approaches to characterise specific regulators. As well as improving our fundamental understanding of redox control of gene expression in bacteria, this project should yield new possibilities for the development of new industrially important strains and tools.
The successful candidate will be a dynamic and motivated individual with a relevant academic background (e.g. Biochemistry). The student will be based at the University of Sussex, but interact closely with scientists at TMO Renewables, including extended research visits.
Funding Notes
The project is funded through BBSRC Industrial CASE award with TMO Renewables for 4 years from September 2012. The stipend is at the standard research council rate plus a supplement from TMO Renewables. The studentship is only available to UK nationals and EU students who meet the UK residency requirements.
Formal applications should be made at http://www.sussex.ac.uk/study/pg/applying/
While applying please send a full CV, a statement of interest, academic transcripts and two references. Mention Mark Paget as the suggested supervisor in the application
For informal project enquiries email Dr Mark Paget ([Email Address Removed]). For application enquiries email Dr Deeptima Massey ([Email Address Removed]).
Formal applications should be made at http://www.sussex.ac.uk/study/pg/applying/
While applying please send a full CV, a statement of interest, academic transcripts and two references. Mention Mark Paget as the suggested supervisor in the application
For informal project enquiries email Dr Mark Paget ([Email Address Removed]). For application enquiries email Dr Deeptima Massey ([Email Address Removed]).
References
McLaughlin, K. J., C. M. Strain-Damerell, K. Xie, D. Brekasis, A. S. Soares, M. S. Paget & C. L. Kielkopf, (2010) Structural Basis for NADH/NAD(+) Redox Sensing by a Rex Family Repressor. Mol Cell 38: 563-575.
Cripps RE, Eley K, Leak DJ, Rudd B, Taylor M, Todd M, Boakes S, Martin S and Atkinson T (2009) Metabolic engineering of Geobacillus thermoglucosidasius for high yield ethanol production. Metab. Eng 11:398-408.
Cripps RE, Eley K, Leak DJ, Rudd B, Taylor M, Todd M, Boakes S, Martin S and Atkinson T (2009) Metabolic engineering of Geobacillus thermoglucosidasius for high yield ethanol production. Metab. Eng 11:398-408.
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