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Dr Y Mehellou
Applications accepted all year round
Self-Funded PhD Students Only
About the Project
Institution: University of Birmingham
Dept./School/Faculty: School of Clinical and Experimental Medicine
PhD Supervisor: Dr. Youcef Mehellou
Application Deadline: applications accepted all year around
Funding availability: self-funded PhD students
Microscale organisation of cells in vitro is proving to be a very powerful technology with many applications across a wide range of disciplines. In particular, the ability to construct synthetic microtissues in vitro in 3-dimensional (3-D) structures holds great promise in understanding how cells are affected by their surrounding environments. These synthetic microtissues will be extremely valuable in understanding contact-dependent signalling events that play critical roles in many cellular processes, e.g. the control of cell cycle, migratory potential, and differentiation state, which inflict significant influence on the structure and behaviour of the tissues they make up. Therefore, having strategies that allow the in vitro programmed assembly of synthetic versions of normal multi-cell type tissues in their 3-D forms would facilitate the understanding of the biochemical events that take place within cellular microenvironments. This project will focus on the development of chemical strategies that can be used to assemble cells together into architecturally complex 3D shapes. The constructed synthetic microtissues will then be used to address fundamental questions in biology that are relevant to human health.
This project is an interdisciplinary initiative that involves many skills such as synthetic chemistry, biochemistry, cell culture and proteomics. From working on this project, the PhD candidate will learn many skills and techniques that will be extremely valuable for those wishing to pursue a career in academia or with pharmaceutical/biotechnology companies.
The work will be based at the School of Clinical and Experimental Medicine with very close collaboration with the School of Chemistry, University of Birmingham. Contact Dr. Youcef Mehellou ([Email Address Removed]) for informal inquiries.
Dept./School/Faculty: School of Clinical and Experimental Medicine
PhD Supervisor: Dr. Youcef Mehellou
Application Deadline: applications accepted all year around
Funding availability: self-funded PhD students
Microscale organisation of cells in vitro is proving to be a very powerful technology with many applications across a wide range of disciplines. In particular, the ability to construct synthetic microtissues in vitro in 3-dimensional (3-D) structures holds great promise in understanding how cells are affected by their surrounding environments. These synthetic microtissues will be extremely valuable in understanding contact-dependent signalling events that play critical roles in many cellular processes, e.g. the control of cell cycle, migratory potential, and differentiation state, which inflict significant influence on the structure and behaviour of the tissues they make up. Therefore, having strategies that allow the in vitro programmed assembly of synthetic versions of normal multi-cell type tissues in their 3-D forms would facilitate the understanding of the biochemical events that take place within cellular microenvironments. This project will focus on the development of chemical strategies that can be used to assemble cells together into architecturally complex 3D shapes. The constructed synthetic microtissues will then be used to address fundamental questions in biology that are relevant to human health.
This project is an interdisciplinary initiative that involves many skills such as synthetic chemistry, biochemistry, cell culture and proteomics. From working on this project, the PhD candidate will learn many skills and techniques that will be extremely valuable for those wishing to pursue a career in academia or with pharmaceutical/biotechnology companies.
The work will be based at the School of Clinical and Experimental Medicine with very close collaboration with the School of Chemistry, University of Birmingham. Contact Dr. Youcef Mehellou ([Email Address Removed]) for informal inquiries.
Funding Notes
Funding notes:
This project is available for UK, EU and International students who have their own funding.
This project is available for UK, EU and International students who have their own funding.
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