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  Integrative In vitro and In silico Modelling of Arterial Mechanobiology for Health and Disease


   School of Computer Science

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Dr P Watton  Applications accepted all year round

About the Project

Supervisor: Dr Paul Watton, Department of Computer Science & INSIGNEO Institute
Co-supervisor: Dr Cecile Perrault, Department of Mechanical Engineering & INSIGNEO Institute

We are seeking applications from motivated science, engineering or life science graduates from India who are interested in studying for a PhD in an exciting interdisciplinary environment.

Arterial mechanobiology relates to the interaction of mechanics with arterial biology. It governs the physiological function and adaption of arteries during development and disease. Improved understanding and modelling of arterial mechanobiology offers the potential to provide fundamental insights into disease processes and guide disease management and treatment.

‘Integrative In vitro and In silico Modelling of Arterial Mechanobiology for Health and Disease’ is a recent collaborative initiative between the University of Sheffield and the Indian Institute of Science, Bangalore and is funded by the UK-India Education and Research Initiative (UKIERI). It brings together two internationally leading vascular mechanobiology research groups: Dr Paul Watton head the Theoretical Mechanobiology research group at Sheffield (www.themebio.org) and Prof Namrata Gundiah heads a Biomechanics Laboratory (www.mecheng.iisc.ernet.in/~namrata). One Indian PhD scholarship is attached to this initiative. A student with an interest in both experimental and computational vascular biomechanics is sought. The novel project will involve experimental and computational modelling of the mechanobiology of a vascular cell-seeded scaffold housed within a flow-bioreactor system developed by Dr Cecile Perrault who leads the Cellular Mechanics and Microfluidics Group (http://cmm.group.shef.ac.uk). The student will be a member of the INSIGNEO Institute of In Silico Medicine (http://insigneo.org).

The Vice Chancellors Indian Scholarship studentship will include full payment of overseas tuition fees along with an annual, tax-free maintenance stipend at the standard UK Research rate (£13,863 in 2014-15). Additional funding is in place to support visits and interactions with Prof Gundiah’s research group at Indian Institute of Science, Bangalore during the PhD. The successful candidate will be expected to have a good 2:1 or 1st class degree in an Engineering or Science subject with laboratory experience and interest in modelling of soft-biological tissues.

For an informal discussion on the project please email Dr. Paul Watton: [Email Address Removed]



Funding Notes

Awards are open to Indian applicants only, who are currently Indian residents and who have a first degree from an Indian Institution. You should meet the entry requirements for a PhD as stated at http://www.sheffield.ac.uk/international/countries/asia/south-asia/india/entry

You should be applying to start your first year of study on a full-time PhD with the University in the 2014-15 academic year (i.e. after 1st August 2014, exact start date to be agreed with your supervisor/department).