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  Organised Natural Structures using Synthetic Biology.


   Department of Bioengineering

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Dr T Ellis  No more applications being accepted

About the Project

We invite applications for an exciting Leverhulme-funded PhD studentship based in the Department of Bioengineering and the Centre for Synthetic Biology and Innovation at Imperial College London. A stipend and home/EU fees for 3 years will be awarded
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The project will initiate research into programming living microbes to build useful and interesting structures. Natural biology is highly skilled at constructing structures such as coral reefs and multicellular organisms, and inspired by this, the project here will research using programmable synthetic biology to produce new microstructures useful for a variety of applications, as well as for art and design. The PhD student will use the model microbe yeast (S. cerevisiae) as the basis for experimental work and will introduce both mathematical modelling and work on art and design into their project.

Applicants should have a Biosciences Masters Degree (or equivalent qualification) in a relevant area (e.g. synthetic biology, microbiology, molecular biology, biotechnology, systems biology, etc.) in order to undertake the experimental part of this project. Experience in the iGEM competition or in the modelling and analysis of biological systems is preferable. We will look specifically for independently motivated applicants with excellent interpersonal, written and oral communication skills and with enthusiasm for being part of ground-breaking collaborations with diverse teams.

More information on research activities in Dr Ellis’ group is found in http://openwetware.org/wiki/Ellis

For further details of the post contact Dr Tom Ellis ([Email Address Removed]). Interested applicants should send a current Curriculum Vitae and a 1-page research statement to Dr Ellis by e-mail.

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Project supervisors

Career overview

Tom Ellis is a Professor of Synthetic Genome Engineering in the Department of Bioengineering at Imperial College London. He obtained his PhD from the University of Cambridge in 2004, where he researched drugs that bind directly to the promoter elements of cancer genes under the supervision of Michael J. Waring. Following his PhD, he worked at the biotech company Spirogen, establishing a biological screening unit and developing high-throughput assays to characterise drug interactions with oncogene promoters. In 2006, Prof. Ellis returned to academia, spending two years at Boston University in the USA, where he investigated synthetic biology in one of the founding groups of the field under the supervision of Jim Collins. During this time, he devised a synthesis-based library approach to engineering gene regulatory networks, successfully modelling and implementing this method in nonlinear systems relevant to biofuel and beer production. Before joining Imperial College in 2009, he returned to the UK to conduct research in synthetic biology at the Institute of Biotechnology at the University of Cambridge. Prof. Ellis has authored over 60 publications in synthetic biology, contributing to prestigious journals such as Science, Cell, Nature Methods, Nature Biotechnology, PNAS, and Nature Reviews. He has led a UK-funded project to construct a synthetic yeast chromosome for the international synthetic yeast project (Sc2.0) and has been a pioneer in the field of Engineered Living Materials. He co-leads the teaching of Imperial’s synthetic biology undergraduate module and has received multiple awards for his teaching and supervision of iGEM teams. His research focuses on developing foundational tools for design-led synthetic genomics and synthetic biology, particularly in yeast (S. cerevisiae), and includes projects aimed at growing new functional biomaterials, alongside various other synthetic biology projects relevant to industry and medicine.


Research interests

Tom Ellis''s main research interests include synthetic genomics, engineered living materials, synthetic biology, genome engineering, the function of DNA sequence, and programming biosynthesis of new therapeutics. He leads a research team focused on developing foundational tools for design-led synthetic genomics and synthetic biology, with particular emphasis on projects involving yeast (S. cerevisiae) aimed at growing new functional biomaterials. His group also engages in a variety of synthetic biology projects relevant to industry and medicine. Tom Ellis has authored over 60 publications in synthetic biology, contributing to prestigious journals such as Science, Cell, Nature Methods, Nature Biotechnology, PNAS, and Nature Reviews. He has been a pioneer in the field of Engineered Living Materials and has led significant projects, including the UK-funded initiative to build a synthetic yeast chromosome for the international synthetic yeast project (Sc2.0).

View Prof. Tom Ellis's profile