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Dr A Del Rio Hernandez
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
We seek a highly motivated individual for a PhD position available in the Department of Bioengineering at Imperial College London (South Kensington Campus), working in the Cellular and Molecular Mechanotransduction Group.
In our group, we use in vivo and in vitro biophysical techniques to investigate the effect of mechanical forces on the behaviour of cells and molecules. We are particularly interested in the study of the mechanisms that govern mechanotransduction in normal cells and how these mechanisms are altered or lost in different cancer scenarios. The candidate is expected to use single molecule techniques (sm), smAFM, smFRET, and smTIRF to elucidate how mechanical forces modulate the networks of interactions of proteins in physiological and pathological conditions. The study will be mainly focused on proteins responsible for cell-cell and cell-extracellular matrix interactions.
UK Applicants should have an upper second class 2:1 or first class degree in Chemistry, Biology, Physics, Engineering, or related discipline. Non UK applicants are expected to hold an equivalent degree. Interested candidates should submit a CV and a cover letter (no longer than one page) clearly indicating the motivations to pursue a PhD in the proposed field to Dr. Armando E. del Rio Hernandez ([Email Address Removed]).
Start date: Summer 2013
In our group, we use in vivo and in vitro biophysical techniques to investigate the effect of mechanical forces on the behaviour of cells and molecules. We are particularly interested in the study of the mechanisms that govern mechanotransduction in normal cells and how these mechanisms are altered or lost in different cancer scenarios. The candidate is expected to use single molecule techniques (sm), smAFM, smFRET, and smTIRF to elucidate how mechanical forces modulate the networks of interactions of proteins in physiological and pathological conditions. The study will be mainly focused on proteins responsible for cell-cell and cell-extracellular matrix interactions.
UK Applicants should have an upper second class 2:1 or first class degree in Chemistry, Biology, Physics, Engineering, or related discipline. Non UK applicants are expected to hold an equivalent degree. Interested candidates should submit a CV and a cover letter (no longer than one page) clearly indicating the motivations to pursue a PhD in the proposed field to Dr. Armando E. del Rio Hernandez ([Email Address Removed]).
Start date: Summer 2013
Funding Notes
This is a fully funded European Research Council PhD position (bursary, consumables, and tuition fees) in the Cellular and Molecular Mechanotransduction Group, open to UK and EU candidates. The position also includes travel funds to visit other laboratories working with complementary approaches.
UK Applicants should have an upper second class 2:1 or first class degree in Chemistry, Biology, Physics, Engineering, or related discipline. Non UK applicants are expected to hold an equivalent degree.
UK Applicants should have an upper second class 2:1 or first class degree in Chemistry, Biology, Physics, Engineering, or related discipline. Non UK applicants are expected to hold an equivalent degree.
References
1. del Rio, A.; Perez-Jimenez, R.; Ruchuan, L.; R; Roca-Cusachs, P.; Fernandez, J. M. and Sheetz, M.P. (2009) Stretching Single Talin Rod Molecules Activates Vinculin Binding. Science 323, 638-641.
2. Schwartz MA. (2009) The force is with us. Science 323 (5914): 588-9.
3. Heinrichs A. (2009) Switch and Stretch. Nature Reviews Molecular Cell Biology 10, 163.
4. Aubin-Tam ME, Olivares AO, Sauer RT, Baker TA, Lang MJ. (2011) Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell 145(2): 257-67.
5. Maillard RA, Chistol G, Sen M, Righini M, Tan J, Kaiser CM, Hodges C, Martin A, Bustamante C. (2011) ClpX(P) generates mechanical force to unfold and translocate its protein substrates. Cell 145(3):459-69.
2. Schwartz MA. (2009) The force is with us. Science 323 (5914): 588-9.
3. Heinrichs A. (2009) Switch and Stretch. Nature Reviews Molecular Cell Biology 10, 163.
4. Aubin-Tam ME, Olivares AO, Sauer RT, Baker TA, Lang MJ. (2011) Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell 145(2): 257-67.
5. Maillard RA, Chistol G, Sen M, Righini M, Tan J, Kaiser CM, Hodges C, Martin A, Bustamante C. (2011) ClpX(P) generates mechanical force to unfold and translocate its protein substrates. Cell 145(3):459-69.
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