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Prof Alex Tonks, Prof R Darley
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
PhD studentship opportunities in the Department of Haematology, Cardiff
Applications are sought from outstanding and enthusiastic UK/EU science graduates ideally with relevant laboratory experience. The project will study the cell biology of leukaemia (see below) and will be undertaken in the Department of Haematology, one of the largest centres for the study of blood diseases in the UK. The student will be required to integrate knowledge of tumour biology, cell signalling and haematopoietic development. Techniques will include subcloning, retroviral gene transduction, flow cytometry, western blotting, gene expression and cell biology.
The successful candidate will join a group of 10 members (PhD students, post-docs and technicians) based in the Tonks/Darley AML Research Group. This group has an excellent track record centred on integrating fundamental research on haematopoietic development and leukaemia with translational and preclinical studies aimed at drug targeting of molecular abnormalities.
Project descriptions:-
Acute Myeloid Leukemia (AML) is a blood cancer arising from disruption of normal blood cell development. With conventional treatment over half of AML patients die from this disease, so the aim of these projects is to understand the complex and highly heterogeneous molecular mechanisms underlying AML to allow the development of targeted therapies. The projects will examine reactive oxygen species (ROS) and its role in modulating glycolytic metabolism.
The role of reactive oxygen species (ROS) in AML.
This is a Tenovus funded studentship. ROS are usually thought to play a role in bacterial killing but have more recently been identified as regulatory molecules of growth and development. Although we know the importance of ROS in immunity, leukaemia and cancer development, we do not know the mechanism of how ROS contributes to AML development. This study will determine how ROS can promote leukaemia and whether it involves pathways perturbing glucose metabolism.
Please send a CV and covering letter to [Email Address Removed]
Applications are sought from outstanding and enthusiastic UK/EU science graduates ideally with relevant laboratory experience. The project will study the cell biology of leukaemia (see below) and will be undertaken in the Department of Haematology, one of the largest centres for the study of blood diseases in the UK. The student will be required to integrate knowledge of tumour biology, cell signalling and haematopoietic development. Techniques will include subcloning, retroviral gene transduction, flow cytometry, western blotting, gene expression and cell biology.
The successful candidate will join a group of 10 members (PhD students, post-docs and technicians) based in the Tonks/Darley AML Research Group. This group has an excellent track record centred on integrating fundamental research on haematopoietic development and leukaemia with translational and preclinical studies aimed at drug targeting of molecular abnormalities.
Project descriptions:-
Acute Myeloid Leukemia (AML) is a blood cancer arising from disruption of normal blood cell development. With conventional treatment over half of AML patients die from this disease, so the aim of these projects is to understand the complex and highly heterogeneous molecular mechanisms underlying AML to allow the development of targeted therapies. The projects will examine reactive oxygen species (ROS) and its role in modulating glycolytic metabolism.
The role of reactive oxygen species (ROS) in AML.
This is a Tenovus funded studentship. ROS are usually thought to play a role in bacterial killing but have more recently been identified as regulatory molecules of growth and development. Although we know the importance of ROS in immunity, leukaemia and cancer development, we do not know the mechanism of how ROS contributes to AML development. This study will determine how ROS can promote leukaemia and whether it involves pathways perturbing glucose metabolism.
Please send a CV and covering letter to [Email Address Removed]
Funding Notes
UK/EU tuition fees only (if applicable, any eligible non-EU candidates must fund the remainder of the overseas fee)
Doctoral Stipend matching UK Research Council National Minimum (£13,726 p.a. for 2012/13, updated each year)
Doctoral Stipend matching UK Research Council National Minimum (£13,726 p.a. for 2012/13, updated each year)
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