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Prof D Parker
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
A funded studentship is available for 39 months to work with Prof David Parker and Dr L-O Palsson, in Durham. The work is broad in scope and you would join a medium sized and well-resourced group, and be given the space to develop different aspects of the project with either a synthetic, mechanistic or instrumentational bias.
A circularly polarized emission spectrometer has recently been built and (the first) microscope suitable for biological samples is being devised in Durham based on a Leica SPII confocal microscope system. In parallel, enantiopure probes are being created based on well-defined lanthanide(III) complexes, that can provide unique information on the chiral microenvironment. Probes that are selective for abundant acute phase proteins are being developed that signal their interaction with the protein through modulation of the circular polarisation of the emitted light. Studies in cellulo are planned to demonstrate efficacy.
In addition, the scope of ‘tagging’ processible thin films or small particles with strongly emissive chiral Ln complexes will be assessed, and the use of circularly polarized luminescence (CPL) sought to report their presence using the microscopy/spectroscopy facility. Such an approach is unique and may have implications for security labelling. A further aspect is to devise immobilized CPL-active probes that also respond to modulation of a given chemical parameter, e.g. variation of T, pH or a chiral additive (lactate/ascorbate/phospho-Tyr residue or a phosphorylated entity on a cell surface) following contact with a complex fluid, bio-fluid or cell culture medium.
Contact: [Email Address Removed]
A circularly polarized emission spectrometer has recently been built and (the first) microscope suitable for biological samples is being devised in Durham based on a Leica SPII confocal microscope system. In parallel, enantiopure probes are being created based on well-defined lanthanide(III) complexes, that can provide unique information on the chiral microenvironment. Probes that are selective for abundant acute phase proteins are being developed that signal their interaction with the protein through modulation of the circular polarisation of the emitted light. Studies in cellulo are planned to demonstrate efficacy.
In addition, the scope of ‘tagging’ processible thin films or small particles with strongly emissive chiral Ln complexes will be assessed, and the use of circularly polarized luminescence (CPL) sought to report their presence using the microscopy/spectroscopy facility. Such an approach is unique and may have implications for security labelling. A further aspect is to devise immobilized CPL-active probes that also respond to modulation of a given chemical parameter, e.g. variation of T, pH or a chiral additive (lactate/ascorbate/phospho-Tyr residue or a phosphorylated entity on a cell surface) following contact with a complex fluid, bio-fluid or cell culture medium.
Contact: [Email Address Removed]
