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Dr S Yarwood
No more applications being accepted
About the Project
Deadline: Rolling selection process. First round application closing date: May 6 2013. Second round closing date: July 1 2013
Stipend: £13,726 per annum
Start date: October 2013
This MRC funded project provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, www.mrc.ac.uk
IL-6 is an atherogenic cytokine that induces pro-inflammatory gene expression by activating the JAK/STAT signalling pathway. One crucial mechanism for down-regulating JAK/STAT signalling is via the SOCS (suppressor of cytokine signalling) family of proteins, which have an important protective role in acute and chronic inflammatory disease. Novel treatments based on the regulation of SOCS3 levels in vascular endothelial cells could therefore have extremely important value in the treatment of diseases like atherosclerosis. We have identified a heterocyclic small molecule (MW <300) from a screen of compounds that can positively regulate the transcription of the SOCS3 gene. Our aims are to identify more potent compounds and to determine how they control SOCS3 expression. Using this approach, we will identify their protein target and validate whether it is therapeutically relevant as a new way to treat atherosclerosis.
Visit our website for more information: http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0
Applicant Instructions
These are 3.5-year PhD studentships and students should apply online here: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/
Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in a relevant subject. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a conference allowance.
On the Programme of Study section of the application please select “MVLS PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s).
Please ensure that all supporting documents are uploaded at point of application, for example:
- Copy of Academic and Professional qualifications
- CV (including letter of application/personal statement)
- 2 x references
Further supporting documents are requested on the online applications system, and should be uploaded where relevant. General enquiries regarding the programme and application procedure should be directed to Alexis Merry: [Email Address Removed]
Stipend: £13,726 per annum
Start date: October 2013
This MRC funded project provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, www.mrc.ac.uk
IL-6 is an atherogenic cytokine that induces pro-inflammatory gene expression by activating the JAK/STAT signalling pathway. One crucial mechanism for down-regulating JAK/STAT signalling is via the SOCS (suppressor of cytokine signalling) family of proteins, which have an important protective role in acute and chronic inflammatory disease. Novel treatments based on the regulation of SOCS3 levels in vascular endothelial cells could therefore have extremely important value in the treatment of diseases like atherosclerosis. We have identified a heterocyclic small molecule (MW <300) from a screen of compounds that can positively regulate the transcription of the SOCS3 gene. Our aims are to identify more potent compounds and to determine how they control SOCS3 expression. Using this approach, we will identify their protein target and validate whether it is therapeutically relevant as a new way to treat atherosclerosis.
Visit our website for more information: http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0
Applicant Instructions
These are 3.5-year PhD studentships and students should apply online here: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/
Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in a relevant subject. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a conference allowance.
On the Programme of Study section of the application please select “MVLS PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s).
Please ensure that all supporting documents are uploaded at point of application, for example:
- Copy of Academic and Professional qualifications
- CV (including letter of application/personal statement)
- 2 x references
Further supporting documents are requested on the online applications system, and should be uploaded where relevant. General enquiries regarding the programme and application procedure should be directed to Alexis Merry: [Email Address Removed]
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