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Dr M MacLeod, Prof P Garside
No more applications being accepted
About the Project
Deadline: Rolling selection process. First round application closing date: May 6 2013. Second round closing date: July 1 2013
Stipend: £13,726 per annum
Start date: October 2013
This MRC funded project provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, www.mrc.ac.uk
Autoimmune diseases, such as rheumatoid arthritis (RA), occur when an individual’s immune system responds to molecules within their own organs. This self-reactivity causes tissue damage that in RA leads to painful joint swelling and destruction. Current treatments can abrogate some factors responsible for this pathology but rarely achieve remission.
CD4 T cells are implicated in the initial stages of RA and play a continued role in chronic inflammation. A greater understanding of how to switch off these CD4 T cells will provide the means to design novel, rationally targeted therapeutics. However, autoimmune patients are diagnosed following disease onset, after self-reactive CD4 T cells have been activated. These activated or memory CD4 T cells are harder to control than naïve cells and we know little about the molecular signals required to switch them off.
The aim of this studentship is to investigate the molecular pathways that enable memory CD4 T cells to translate external signals into cellular decisions, in particular the decision to live or die. Using a range of in vivo mouse models and ex vivo cell assays with CD4 T cell from RA patients, this studentship offers training across a wide range of techniques. The project will generate important data that could lead to new targets to permanently turn off self-reactive CD4 T cells and thereby control RA.
Visit our website for more information: http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0
Applicant Instructions
These are 3.5-year PhD studentships and students should apply online here: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/
Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in a relevant subject. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a conference allowance.
On the Programme of Study section of the application please select “MVLS PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s).
Please ensure that all supporting documents are uploaded at point of application, for example:
- Copy of Academic and Professional qualifications
- CV (including letter of application/personal statement)
- 2 x references
Further supporting documents are requested on the online applications system, and should be uploaded where relevant. General enquiries regarding the programme and application procedure should be directed to Alexis Merry: [Email Address Removed]
Stipend: £13,726 per annum
Start date: October 2013
This MRC funded project provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, www.mrc.ac.uk
Autoimmune diseases, such as rheumatoid arthritis (RA), occur when an individual’s immune system responds to molecules within their own organs. This self-reactivity causes tissue damage that in RA leads to painful joint swelling and destruction. Current treatments can abrogate some factors responsible for this pathology but rarely achieve remission.
CD4 T cells are implicated in the initial stages of RA and play a continued role in chronic inflammation. A greater understanding of how to switch off these CD4 T cells will provide the means to design novel, rationally targeted therapeutics. However, autoimmune patients are diagnosed following disease onset, after self-reactive CD4 T cells have been activated. These activated or memory CD4 T cells are harder to control than naïve cells and we know little about the molecular signals required to switch them off.
The aim of this studentship is to investigate the molecular pathways that enable memory CD4 T cells to translate external signals into cellular decisions, in particular the decision to live or die. Using a range of in vivo mouse models and ex vivo cell assays with CD4 T cell from RA patients, this studentship offers training across a wide range of techniques. The project will generate important data that could lead to new targets to permanently turn off self-reactive CD4 T cells and thereby control RA.
Visit our website for more information: http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0
Applicant Instructions
These are 3.5-year PhD studentships and students should apply online here: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/
Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in a relevant subject. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a conference allowance.
On the Programme of Study section of the application please select “MVLS PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s).
Please ensure that all supporting documents are uploaded at point of application, for example:
- Copy of Academic and Professional qualifications
- CV (including letter of application/personal statement)
- 2 x references
Further supporting documents are requested on the online applications system, and should be uploaded where relevant. General enquiries regarding the programme and application procedure should be directed to Alexis Merry: [Email Address Removed]
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