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Dr Karen Keeshan, Prof Tessa Holyoake
No more applications being accepted
About the Project
Deadline: Rolling selection process. First round application closing date: May 6 2013. Second round closing date: July 1 2013
Stipend: £13,726 per annum
Start date: October 2013
This MRC funded project provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, www.mrc.ac.uk
The TRIB family of pseudokinase genes have recently emerged as having important roles in proliferation, survival, motility, and metabolism. There is a strong correlation between dysregulated Trib expression, acute myeloid (AML) and lymphoid Leukaemia (ALL) and cell proliferation. Our previous work has shown that elevated TRIB2 oncogene expression correlates with a specific subset of AML and ALL with NOTCH1 mutatons and dysregulated C/EBPalpa. However, how and where TRIB expression is regulated in normal and malignant haematopoiesis is poorly understood, nor is it known what signals control the expression of Trib proteins in a cell-type, cell-context, and cell-cycle dependent manner. Our work indicates that the cell cycle regulator E2F1 plays a key role in the control of Trib2 expression. Our hypothesis is that dysregulated E2F1 and cell cycle pathways contribute to increased Trib2 expression, leading to the degradation of key proteins that are important for normal haematopoietic differentiation, resulting in the differenentiation block and increased proliferation seen in acute leukaemic disease. Understanding the E2F1-Trib2 axis and the regulation of this pathway and the downstream effects of such regulation has important biological significance to the development of new targeted therapies in leukaemia. This proposal aims to investigate the regulation of the E2F1-Trib2 relationship during normal haematopoiesis and specifically in AML.
Visit our website for more information: http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0
Applicant Instructions
These are 3.5-year PhD studentships and students should apply online here: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/
Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in a relevant subject. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a conference allowance.
On the Programme of Study section of the application please select “MVLS PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s).
Please ensure that all supporting documents are uploaded at point of application, for example:
- Copy of Academic and Professional qualifications
- CV (including letter of application/personal statement)
- 2 x references
Further supporting documents are requested on the online applications system, and should be uploaded where relevant. General enquiries regarding the programme and application procedure should be directed to Alexis Merry: [Email Address Removed]
Stipend: £13,726 per annum
Start date: October 2013
This MRC funded project provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, www.mrc.ac.uk
The TRIB family of pseudokinase genes have recently emerged as having important roles in proliferation, survival, motility, and metabolism. There is a strong correlation between dysregulated Trib expression, acute myeloid (AML) and lymphoid Leukaemia (ALL) and cell proliferation. Our previous work has shown that elevated TRIB2 oncogene expression correlates with a specific subset of AML and ALL with NOTCH1 mutatons and dysregulated C/EBPalpa. However, how and where TRIB expression is regulated in normal and malignant haematopoiesis is poorly understood, nor is it known what signals control the expression of Trib proteins in a cell-type, cell-context, and cell-cycle dependent manner. Our work indicates that the cell cycle regulator E2F1 plays a key role in the control of Trib2 expression. Our hypothesis is that dysregulated E2F1 and cell cycle pathways contribute to increased Trib2 expression, leading to the degradation of key proteins that are important for normal haematopoietic differentiation, resulting in the differenentiation block and increased proliferation seen in acute leukaemic disease. Understanding the E2F1-Trib2 axis and the regulation of this pathway and the downstream effects of such regulation has important biological significance to the development of new targeted therapies in leukaemia. This proposal aims to investigate the regulation of the E2F1-Trib2 relationship during normal haematopoiesis and specifically in AML.
Visit our website for more information: http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0
Applicant Instructions
These are 3.5-year PhD studentships and students should apply online here: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/
Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in a relevant subject. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a conference allowance.
On the Programme of Study section of the application please select “MVLS PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s).
Please ensure that all supporting documents are uploaded at point of application, for example:
- Copy of Academic and Professional qualifications
- CV (including letter of application/personal statement)
- 2 x references
Further supporting documents are requested on the online applications system, and should be uploaded where relevant. General enquiries regarding the programme and application procedure should be directed to Alexis Merry: [Email Address Removed]
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