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Dr Yuhang Chen, Prof JM Ritchie
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
A PhD studentship, supervised by Dr. Y Chen and Prof. JM Ritchie, is now available in School of Engineering and Physical Sciences at Heriot-Watt University (Edinburgh, UK) for UK students and eligible EU students.
Scaffolding as a tissue engineering approach has drawn significant attention in bioengineering community in the past two decades. In principle the tissue scaffolds are expected to be porous, biodegradable and able to provide cell-friendly environment for cell growth during the regenerative process. In this regard, design of scaffold microstructure would be crucial therefore must be taken into account in studying such a dynamically- changing tissue-scaffold system. The first part of this project is to develop a computational framework that characterises the bone tissue-scaffold system in vivo, by addressing the microenvironment (both mechanical and biochemical), scaffold biodegradation, interactions with host tissue (acquisition of complicated 3D wound cavity by imaging with different fixation methods; cell migration and mass diffusion), the cellular mechanobiological response and neovascularisation. The established models will then be used as a framework for design optimisation of scaffold microstructures, which will be fabricated by our state-of-the-art biofabrication facilities.
The ideal candidate should be highly-motivated and have experience in computational mechanics or related fields. Prior experience in programming in one or more of the following languages is a plus: Matlab, Python (ABAQUS) or APDL (ANSYS). Good interpersonal skills are needed as successful candidate will be involved in a wider range of researchers of mathematical modellers, material scientists, bioengineers and bone clinicians.
Scaffolding as a tissue engineering approach has drawn significant attention in bioengineering community in the past two decades. In principle the tissue scaffolds are expected to be porous, biodegradable and able to provide cell-friendly environment for cell growth during the regenerative process. In this regard, design of scaffold microstructure would be crucial therefore must be taken into account in studying such a dynamically- changing tissue-scaffold system. The first part of this project is to develop a computational framework that characterises the bone tissue-scaffold system in vivo, by addressing the microenvironment (both mechanical and biochemical), scaffold biodegradation, interactions with host tissue (acquisition of complicated 3D wound cavity by imaging with different fixation methods; cell migration and mass diffusion), the cellular mechanobiological response and neovascularisation. The established models will then be used as a framework for design optimisation of scaffold microstructures, which will be fabricated by our state-of-the-art biofabrication facilities.
The ideal candidate should be highly-motivated and have experience in computational mechanics or related fields. Prior experience in programming in one or more of the following languages is a plus: Matlab, Python (ABAQUS) or APDL (ANSYS). Good interpersonal skills are needed as successful candidate will be involved in a wider range of researchers of mathematical modellers, material scientists, bioengineers and bone clinicians.
Funding Notes
Due to the restriction of funding resource, this is a 3.5 year scholarship for UK students (EU students who have lived in UK for more than 3yrs prior to the start of the grant are also eligible). It will cover tuition fee as well as carrying an annual stipend of £13,590.
References
*Evaluation of candidates will begin immediately and will continue until the position is filled.
*Applications and informal academic enquiries should be directed to Dr Yuhang Chen (y.chen@hw.ac.uk), with a copy of your current CV and other supporting documents. All general enquiries should be directed to the Postgraduate Admissions Office (pgadmissions@hw.ac.uk).
*Applications and informal academic enquiries should be directed to Dr Yuhang Chen (y.chen@hw.ac.uk), with a copy of your current CV and other supporting documents. All general enquiries should be directed to the Postgraduate Admissions Office (pgadmissions@hw.ac.uk).
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