4 year PhD in Biomembrane Voltage Sensors

A PhD position is available in the Institute of Biological Chemistry, Biophysics and Bioengineering. In this exciting new project, the successful candidate will carry out a four year research programme on novel classes of voltage -sensitive PTEN- like phosphatases. These proteins are the only example so far of hybrid voltage sensors/cytoplasmic enzymes where enzymatic activity is controlled by transmembrane voltage. Understanding the biophysics of VSPTEN could be very important considering the key roles that ‘conventional’ cytoplasmic PTENs play in tumor suppression and synaptic plasticity. The project will examine the expression and function of VSP-PTEN using tissue and cultured cells as well as examining the potential application of VSPTENs as biophysical tools. The project will take full advantage of the expertise and facilities in HW in the electrophysiology of ion channels (Brown), PTEN molecular function (Leslie) and molecular imaging (Duncan). The candidate will receive a solid training in electrophysiology, imaging and molecular biology.

We are seeking a graduate with a 1st or strong 2:1 First degree in Biosciences, Biophysics or molecular biology. An interest in membrane signaling or biophysics would be an advantage. We are keen that the project should begin as soon as possible and by September 2013 at the very latest.


Interested candidates should contact Dr Euan R Brown ([Email Address Removed]), with a copy of their CV.