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Prof Andrew Ward
Applications accepted all year round
About the Project
Imprinted genes behave unusually in that they are expressed predominantly, if not exclusively, from only one of their two alleles. Dlk1 (also known as preadipocyte factor 1) is expressed from the paternal allele while Grb10 is expressed from the maternal allele in most of the tissues where they are active. We have established that the Grb10 gene acts to suppress growth of both the embryo and placenta as Grb10 knockout mice are born approximately 30% larger than wild type littermates. In adulthood Grb10 knockout mice are lean, with increased muscle mass and reduced adipose. Conversely, Dlk1 knockout mice are small at birth and tend to accumulate excess adipose in adulthood.
The aim is to determine the roles in adipose development of the Grb10 and Dlk1 signalling proteins, each encoded by imprinted genes.
The project will provide training in mouse genetics and development and will involve cell biology, microscopy and molecular techniques.
The aim is to determine the roles in adipose development of the Grb10 and Dlk1 signalling proteins, each encoded by imprinted genes.
The project will provide training in mouse genetics and development and will involve cell biology, microscopy and molecular techniques.
Funding Notes
We welcome year-round applications from Home/EU/Overseas self-funded students and applicants seeking their own funding
Excellent Home/EU/Overseas applicants may also be considered for our highly-competitive tuition fee waiver scholarships. These are very limited and will only cover a portion of the tuition fees.
Excellent Home/EU/Overseas applicants may also be considered for our highly-competitive tuition fee waiver scholarships. These are very limited and will only cover a portion of the tuition fees.
References
For more information about available PhD projects in the department of Biology and Biochemistry at the University of Bath, please see: http://www.bath.ac.uk/bio-sci/postgraduate/phd-projects/
