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Prof Andrew Carnell
Applications accepted all year round
About the Project
Applications are invited for a funded 42 month period of research leading to the award of PhD in the Department of Chemistry, University of Liverpool, UK.
Project Description
Amide bonds are of fundamental importance in chemistry and biology and are found in pharmaceuticals, synthetic polymers and biomolecules. This project concerns the development of molybdenum-dependent enzymes to catalyse the formation of amides using a completely novel approach. These enzymes are well known in drug metabolism but have never been exploited synthetically. We will explore and extend the substrate range of these enzymes using mutagenesis techniques. The molybdenum enzymes will be coupled with other enzymes to develop enzyme cascades for sustainable synthesis of important intermediates for drug synthesis.
Training
In addition to further developing synthetic chemistry skills, you will receive additional training in microbiology and molecular biology. The knowledge and skills developed will provide you with a solid foundation for a future academic or industrial career in the field of industrial biotechnology and sustainable synthesis.
Project Description
Amide bonds are of fundamental importance in chemistry and biology and are found in pharmaceuticals, synthetic polymers and biomolecules. This project concerns the development of molybdenum-dependent enzymes to catalyse the formation of amides using a completely novel approach. These enzymes are well known in drug metabolism but have never been exploited synthetically. We will explore and extend the substrate range of these enzymes using mutagenesis techniques. The molybdenum enzymes will be coupled with other enzymes to develop enzyme cascades for sustainable synthesis of important intermediates for drug synthesis.
Training
In addition to further developing synthetic chemistry skills, you will receive additional training in microbiology and molecular biology. The knowledge and skills developed will provide you with a solid foundation for a future academic or industrial career in the field of industrial biotechnology and sustainable synthesis.
Funding Notes
Funding notes
Creative and highly motivated applicants from UK/EU are encouraged to apply. You should have a 1st or 2i degree or equivalent in Chemistry or related degree with specific experience in one or more of the above fields. You will need to be ambitious and driven to achieve your objectives.
The initial studentship stipend is £13,590 per year.
To apply please send a copy of your curriculum vitae and contact details for two referees to: Dr Andrew Carnell ([Email Address Removed]).
The position is available from 1st October 2013.
Creative and highly motivated applicants from UK/EU are encouraged to apply. You should have a 1st or 2i degree or equivalent in Chemistry or related degree with specific experience in one or more of the above fields. You will need to be ambitious and driven to achieve your objectives.
The initial studentship stipend is £13,590 per year.
To apply please send a copy of your curriculum vitae and contact details for two referees to: Dr Andrew Carnell ([Email Address Removed]).
The position is available from 1st October 2013.
Project supervisors
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