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Prof M Marber
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
British Heart Foundation Centre of Research Excellence
3-year BHF Centre PhD Studentship
The King’s College London British Heart Foundation (BHF) Centre of Research Excellence offers an outstanding environment for cardiovascular research training. It includes a large number of internationally rated investigators whose expertise encompasses a very broad range of cardiac and vascular biomedicine. The unit performed exceedingly well in the recent RAE, being the only institution to be in the top 3 both on average quality score and research power.
We are inviting applications for a joint project studentship to commence from October 2013 that is co-supervised by a KCL-based supervisor, Prof Michael Marber, and a University of Goettingen-based supervisor, Dr Tim Seidler, with complementary expertise. All principal supervisors have a strong track record of publications, grant income and successful supervision.
Targeting p38alpha MAPK
Prof Michael Marber, Dr Tim Seidler
The alpha isoform of p38 mitogen-activated protein kinase (p38α) is expressed in all cells and involved in multiple stress-sensing pathways. Not surprisingly pharmacological and genetic inhibition of this kinase has yielded mixed results in basic science studies and toxicity has also been seen in clinical trials of p38α inhibitors. The purpose of this studentship is to examine a very unusual form of p38α activation that occurs when it binds another protein known as TAB1. The purpose is to define and disrupt the recognition between p38α:TAB1. These experiments will be performed on isolated proteins and in transfected cell lines and use a range of biological and biophysical readouts. The ultimate aim is to develop a small molecule that will disrupt TAB1:p38α complex formation as a potential therapy for ischaemic heart disease.
Further reading
Martin DE, De Nicola GF, Marber MS. New therapeutic targets in cardiology: p38 alpha mitogen-activated protein kinase for ischemic heart disease. Circulation. 2012 Jul 17;126(3):357-68.
Candidates must possess, or be expected to achieve, a 1st or good upper 2nd class degree, ideally in biochemistry, or a relevant subject and must meet BHF residency requirements. Current 1st year BHF stipend rates for London are £22,278 pa.
For further information please visit our website: http://www.kcl.ac.uk/medicine/research/divisions/cardio/research/phd/BHFCREPhD.aspx
Application procedure:
- Apply online https://myapplication.kcl.ac.uk/ for the School of Medicine, Cardiovascular Division MPhil/PhD programme and quote reference 03/13PHDUMG, naming the project of interest instead of including a research proposal.
- Please include a personal statement outlining your suitability for the programme and why you are interested in pursuing a PhD in the subject area.
Closing date: Friday, 7 June, 2013
Enquiries:
Should you have any enquiries please contact Elizabeth Halton, Assistant Divisional Manager, on [Email Address Removed] or (020) 7848 0263.
Please ensure that you quote 03/13PHDUMG on your application and state clearly which project you wish to apply for
3-year BHF Centre PhD Studentship
The King’s College London British Heart Foundation (BHF) Centre of Research Excellence offers an outstanding environment for cardiovascular research training. It includes a large number of internationally rated investigators whose expertise encompasses a very broad range of cardiac and vascular biomedicine. The unit performed exceedingly well in the recent RAE, being the only institution to be in the top 3 both on average quality score and research power.
We are inviting applications for a joint project studentship to commence from October 2013 that is co-supervised by a KCL-based supervisor, Prof Michael Marber, and a University of Goettingen-based supervisor, Dr Tim Seidler, with complementary expertise. All principal supervisors have a strong track record of publications, grant income and successful supervision.
Targeting p38alpha MAPK
Prof Michael Marber, Dr Tim Seidler
The alpha isoform of p38 mitogen-activated protein kinase (p38α) is expressed in all cells and involved in multiple stress-sensing pathways. Not surprisingly pharmacological and genetic inhibition of this kinase has yielded mixed results in basic science studies and toxicity has also been seen in clinical trials of p38α inhibitors. The purpose of this studentship is to examine a very unusual form of p38α activation that occurs when it binds another protein known as TAB1. The purpose is to define and disrupt the recognition between p38α:TAB1. These experiments will be performed on isolated proteins and in transfected cell lines and use a range of biological and biophysical readouts. The ultimate aim is to develop a small molecule that will disrupt TAB1:p38α complex formation as a potential therapy for ischaemic heart disease.
Further reading
Martin DE, De Nicola GF, Marber MS. New therapeutic targets in cardiology: p38 alpha mitogen-activated protein kinase for ischemic heart disease. Circulation. 2012 Jul 17;126(3):357-68.
Candidates must possess, or be expected to achieve, a 1st or good upper 2nd class degree, ideally in biochemistry, or a relevant subject and must meet BHF residency requirements. Current 1st year BHF stipend rates for London are £22,278 pa.
For further information please visit our website: http://www.kcl.ac.uk/medicine/research/divisions/cardio/research/phd/BHFCREPhD.aspx
Application procedure:
- Apply online https://myapplication.kcl.ac.uk/ for the School of Medicine, Cardiovascular Division MPhil/PhD programme and quote reference 03/13PHDUMG, naming the project of interest instead of including a research proposal.
- Please include a personal statement outlining your suitability for the programme and why you are interested in pursuing a PhD in the subject area.
Closing date: Friday, 7 June, 2013
Enquiries:
Should you have any enquiries please contact Elizabeth Halton, Assistant Divisional Manager, on [Email Address Removed] or (020) 7848 0263.
Please ensure that you quote 03/13PHDUMG on your application and state clearly which project you wish to apply for
