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  Anti-cancer drug delivery: developing a predictive in silico model to improve chemotherapy drug delivery


   Leeds Institute of Molecular Medicine

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Dr M.E. Hubbard Dr P Jones  No more applications being accepted  Competition Funded PhD Project (European/UK Students Only)

About the Project

Inadequate drug delivery to tumours is a key factor that limits the efficacy of anti-cancer drugs. Transport of therapeutic agents through the tumour vascular network, followed by their extravasation and penetration through the surrounding tissue, are critically important processes to delivering sufficient drug to have a therapeutic effect. This project aims to design and build a flexible and efficient in silico model which simulates the complete anti-cancer drug delivery process through the tumour vascular network. Of particular interest will be developing a quantitative understanding of the obstacles to drug delivery caused by the chaotic nature of the vascular system within tumours. It will build on a recently developed model (Evans et al., 2009) which simulates transport of the clinically used chemotherapeutic drug doxorubicin across multicell layers. The software will be designed to make it simple to substitute other drugs for which extravascular transport behaviour can be modelled. The ultimate aim is to provide a tool which can be used to optimise drug delivery.

Funding Notes

The project is part of a Cancer Research UK (CRUK) and YCR-funded studentship competition. UK and EU permanent resident students can apply. Applicants should complete the online application form at the following address and send it to the FBS Graduate School [Email Address Removed].
http://www.fbs.leeds.ac.uk/gradschool/keywords/documents/YCR_CRUK-AppForm1213.docx

References

Evans CJ, Phillips RM, Jones PF, Loadman PM, Sleeman BD, Twelves CJ, Smye SW. A mathematical model of doxorubicin penetration through multicellular layers, Journal of Theoretical Biology, 257(4):598--608, 2009.

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Project supervisors

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Career overview

Professor Pam Jones is a prominent academic in the field of biomedical research, currently serving as the Director of the Leeds Institute of Medical Research at St James''s since June 2018. She has held the position of Professor of Biomedical Research since 2012 and previously served as the Pro-Dean for Research & Innovation for the Faculty of Medicine and Health. Her prior roles include Director of St James’s Campus Infrastructure and Facilities from 2011 to 2014, and Deputy Director of the Biomedical & Health Research Centre from 2009 to 2014. Before joining the University of Leeds, Professor Jones held postdoctoral research positions in the Department of Cell Biology at the Biocentre and the Friedrich Miescher Institute in Basel, Switzerland, as well as a Senior Scientist role at Regeneron Pharmaceuticals in Tarrytown, NY, USA. Professor Jones has a strong academic background with a BA (Hons) in Biochemistry, an MA, and a D.Phil. from the University of Oxford. Her research expertise encompasses molecular biology, angiogenesis, and cell biology, with a focus on the role of endothelial cells in vascular function. She has made significant contributions to the field, including the cloning of key cellular signalling molecules and holds over 120 GenBank entries along with being an inventor on 10 US and over 50 worldwide patents. Professor Jones is a Fellow of the Higher Education Academy and is affiliated with the British Microcirculation and Vascular Biology Society and the European Microcirculation Society.


Research interests

Professor Jones''s research focuses on molecular biology, specifically in the areas of angiogenesis and the role of endothelial cells in vascular function. She has an extensive background in cloning key cellular signalling molecules, including PKB (Akt), neurotrophin 4/5, noggin, various forms of EGFR, Trk and Tie receptor kinases, and all members of the angiopoietin family. Professor Jones is an inventor on 10 US and over 50 worldwide patents and has over 120 GenBank entries. Her work has contributed significantly to understanding the mechanisms of angiogenesis and its implications in various diseases, particularly cancer.

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