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Dr S Nejentsev
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
The Department of Medicine is seeking applications from eligible students who wish to undertake an MRC-funded 3 year PhD studentship starting October 2012. The five research projects available, together with supervisor details, can be found on the Departments website at: http://www.med.cam.ac.uk/mrc-phd-studentship-2012-project-outlines/.
Primary Immunodeficiencies are a heterogeneous group of more than 200 diseases caused by Mendelian mutations in the immune genes. Primary Immunodeficiencies manifest as severe recurrent infection and often can be life-threatening. Mutations in some patients have been identified previously using linkage analysis and candidate gene approach. These discoveries proved to be extremely informative for understanding of the human immune system. Nevertheless, genetic causes in the majority of patients with Primary Immunodeficiencies remain unknown.
The aims of the proposed PhD project are to discover new causative mutations in patients with Primary Immunodeficiencies, to investigate functions of the affected proteins and to uncover new mechanisms of susceptibility to infection. Initially, advanced methods of human genetics will be employed, such as sequencing of exomes and whole genomes of patients, focusing primarily on those suffering from mycobacterial infections. Then a variety of molecular and cell biology techniques will be used, including quantitative PCR, Western blotting, cytokine secretion analyses, immunofluorescence confocal microscopy, electron microscopy, RNA interference, gene cloning and in vitro infection models. These techniques are established in the laboratory and training will be provided. Discovery of new genetic and functional mechanisms of Primary Immunodeficiencies will improve understanding of the immune system and will allow to design new diagnostic assays and new therapeutic approaches that will save patients’ lives.
Post short-list enquiries can be made to Professor Edwin Chilvers ([Email Address Removed]).
Fixed-term: The funds for this studentship are available for 3 years in the first instance.
The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Applicants should submit a full CV, including details of two referees, and a covering letter clearly indicating which of the projects they are interested in to Mrs Linda Whyles via email: [Email Address Removed].
Applications must be received by 5pm on the closing date.
Quote reference: RC00092, Closing date: 19 February 2012.
Primary Immunodeficiencies are a heterogeneous group of more than 200 diseases caused by Mendelian mutations in the immune genes. Primary Immunodeficiencies manifest as severe recurrent infection and often can be life-threatening. Mutations in some patients have been identified previously using linkage analysis and candidate gene approach. These discoveries proved to be extremely informative for understanding of the human immune system. Nevertheless, genetic causes in the majority of patients with Primary Immunodeficiencies remain unknown.
The aims of the proposed PhD project are to discover new causative mutations in patients with Primary Immunodeficiencies, to investigate functions of the affected proteins and to uncover new mechanisms of susceptibility to infection. Initially, advanced methods of human genetics will be employed, such as sequencing of exomes and whole genomes of patients, focusing primarily on those suffering from mycobacterial infections. Then a variety of molecular and cell biology techniques will be used, including quantitative PCR, Western blotting, cytokine secretion analyses, immunofluorescence confocal microscopy, electron microscopy, RNA interference, gene cloning and in vitro infection models. These techniques are established in the laboratory and training will be provided. Discovery of new genetic and functional mechanisms of Primary Immunodeficiencies will improve understanding of the immune system and will allow to design new diagnostic assays and new therapeutic approaches that will save patients’ lives.
Post short-list enquiries can be made to Professor Edwin Chilvers ([Email Address Removed]).
Fixed-term: The funds for this studentship are available for 3 years in the first instance.
The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Applicants should submit a full CV, including details of two referees, and a covering letter clearly indicating which of the projects they are interested in to Mrs Linda Whyles via email: [Email Address Removed].
Applications must be received by 5pm on the closing date.
Quote reference: RC00092, Closing date: 19 February 2012.
Funding Notes
Eligible students will hold a 2(i) class degree and/or a Masters level qualification in a relevant subject. The studentship will cover student stipend, PhD fees and college membership and is available to UK and EU students only. If a student is from an EU country, but cannot demonstrate a relevant connection to the UK through ordinary residence, they may be eligible for a studentship for tuition fees, but not for a maintenance stipend. Non-EU or overseas citizens are not eligible and need not apply.
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