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Prof J Field
Dr J Robinson
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Applications are invited for a 3-year PhD studentship in Lung Cancer Molecular-Epidemiology starting in early 2012 to be held at the Liverpool UK Cancer Research Centre, Institute of Translational Medicine, and the School of Law & Social Justice, The University of Liverpool.
The student will work on the Liverpool Lung Project (LLP) on the project – Lung Cancer risk awareness and smoking future behaviour. This project will explore the impact of lung cancer risk awareness on smoking behaviour and evaluate the hypothesis that individuals with high 5-year absolute risk of lung cancer, predicted using the Liverpool Lung Project (LLP) risk model, are at increased likelihood of quitting smoking.
The aim of this PhD application is to understand the relationship between lung cancer risk, as calculated by the LLP Risk Score and smoking cessation. If we understood this relationship, one could develop targeted smoking cessation programmes aimed at individuals with specific risk categories. The PhD student will utilise a number of current cohort and patient groups; the Liverpool Lung Project Cohort; the LLP COPD-Lung Cohort; patients referred to the Rapid Access Clinics and Lung Cancer patients. There will also be an opportunity to have access to smoking cessation clinics, where the Student will administer the LLP risk model, a psychosocial questionnaire and obtain samples. In addition the PhD student will have access to the genetic susceptibility data and the growing genetic biomarker datasets, which will improve the utility of the LLP risk model. The student will develop future risk projection risk scores which will form the basis of an application to NIHR to undertake a programme to test this approach in primary care populations.
The LLP research team has an emphasis on collaborative working between its constituent research groups, and students will be part of a multidisciplinary team with recognised expertise and will benefit from a strong and well-established research and training environment. As well as daily interaction working with the LLP Biostatistician/Epidemiologist, there will also be opportunity for collaborative work with a team of bioinformaticians and biologist working on the LLP project, as well as contributing to the project managing of the LLP-Chinese project under the supervision of the LLP project management team. This studentship, therefore, offers an excellent opportunity to gain sound research training in a supportive environment in the field of cancer epidemiology.
The project will be suited to a candidate with a biomedical and/or mathematical/statistical background with a strong interest in cancer epidemiology, risk modelling, population genetics, clinical translational research, public health and biostatistical applications. Essential IT skills necessary for handling large and complex dataset are required. Knowledge and/or previous experience working with Stata, SAS or R will be useful. A working knowledge of the health behaviour literature around smoking would be desirable.
The student will work on the Liverpool Lung Project (LLP) on the project – Lung Cancer risk awareness and smoking future behaviour. This project will explore the impact of lung cancer risk awareness on smoking behaviour and evaluate the hypothesis that individuals with high 5-year absolute risk of lung cancer, predicted using the Liverpool Lung Project (LLP) risk model, are at increased likelihood of quitting smoking.
The aim of this PhD application is to understand the relationship between lung cancer risk, as calculated by the LLP Risk Score and smoking cessation. If we understood this relationship, one could develop targeted smoking cessation programmes aimed at individuals with specific risk categories. The PhD student will utilise a number of current cohort and patient groups; the Liverpool Lung Project Cohort; the LLP COPD-Lung Cohort; patients referred to the Rapid Access Clinics and Lung Cancer patients. There will also be an opportunity to have access to smoking cessation clinics, where the Student will administer the LLP risk model, a psychosocial questionnaire and obtain samples. In addition the PhD student will have access to the genetic susceptibility data and the growing genetic biomarker datasets, which will improve the utility of the LLP risk model. The student will develop future risk projection risk scores which will form the basis of an application to NIHR to undertake a programme to test this approach in primary care populations.
The LLP research team has an emphasis on collaborative working between its constituent research groups, and students will be part of a multidisciplinary team with recognised expertise and will benefit from a strong and well-established research and training environment. As well as daily interaction working with the LLP Biostatistician/Epidemiologist, there will also be opportunity for collaborative work with a team of bioinformaticians and biologist working on the LLP project, as well as contributing to the project managing of the LLP-Chinese project under the supervision of the LLP project management team. This studentship, therefore, offers an excellent opportunity to gain sound research training in a supportive environment in the field of cancer epidemiology.
The project will be suited to a candidate with a biomedical and/or mathematical/statistical background with a strong interest in cancer epidemiology, risk modelling, population genetics, clinical translational research, public health and biostatistical applications. Essential IT skills necessary for handling large and complex dataset are required. Knowledge and/or previous experience working with Stata, SAS or R will be useful. A working knowledge of the health behaviour literature around smoking would be desirable.
Funding Notes
A stipend of £14,000 will be payable plus tuition fees at the home/EU rate.
APPLICATION PROCEDURE:
Please send a full CV (including a statement of research experience and names of two referees) to Professor John K. Field. Email: [Email Address Removed].
APPLICATION PROCEDURE:
Please send a full CV (including a statement of research experience and names of two referees) to Professor John K. Field. Email: [Email Address Removed].
References
1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics,2002. CA Cancer J Clin. 2005; 55: 74-108.
2. Maddams J, Moller H, Devane C, . Cancer prevalence in the UK. National Cancer Intelligence Network. 2008.
3. Ganti A, Mulshine J. Lung cancer screening: panacea or pipe dream? Ann Oncol 2005; 16: 215-9.
4. van Klaveren RJ, de Koning HJ, Mulshine J, Hirsch FR. Lung cancer screening by spiral CT. What is the optimal target population for screening trials? Lung Cancer. 2002; 38(3): 243-52.
5. Duffy SW, Raji OY, Agbaje OF, Allgood PC, Cassidy A, Field JK. Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer. Expert Rev Anticancer Ther. 2009; 9(10): 1467-72.
6. Cassidy A, Myles J, van-Tongeren M, Page R, Liloglou T, Duffy S, et al. The LLP risk model: an individual risk prediction model for lung cancer. Br J Cancer. 2008; 98((2)): 270-6.
7. Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. Bmj. 2000; 321(7257): 323-9.
8. Payne S. ‘Smoke like a man, die like a man’?1: A review of the relationship between gender, sex and lung cancer Social Science & Medicine 2001; 53(8): 1067-80
9. Beck U. Risk Society: Towards a New Modernity. London: Sage; 1992.
10. Giddens A. Modernity and self-identity: self and society in the late modern age. Cambridge: Polity Press; 1991.
11. Poland B, Frohlich K, Haines R, Mykhalovskiy E, Rock M, Sparks R. The social context of smoking: the next frontier in tobacco control? Tobacco Control. 2006; 15: 59-63.
12. Bancroft A, Wiltshire S, Parry O, Amos A. "It’s like an addiction first thing… afterwards it's like a habit": daily smoking behaviour among people living in areas of deprivation Social Science & Medicine 2003; 56(6): 1261-7
13. Wiltshire S, Bancroft A, Parry O, Amos A. ‘I came back here and started smoking again’: perceptions and experiences of quitting among disadvantaged smokers Health Education Research. 2003; Vol. 18, No. 3: 292-303.
14. Robinson J, Ritchie D, Amos A, Cunningham-Burley S, Greaves L, Martin C. 'Waiting until they got home': Gender, smoking and tobacco exposure. Social Science & Medicine. 2010; 71: 884-90.
15. Thompson L, Pearce J, Barnett J. Moralising geographies: stigma, smoking islands and responsible subjects. AREA. 2007; 39(4): 508-17.
2. Maddams J, Moller H, Devane C, . Cancer prevalence in the UK. National Cancer Intelligence Network. 2008.
3. Ganti A, Mulshine J. Lung cancer screening: panacea or pipe dream? Ann Oncol 2005; 16: 215-9.
4. van Klaveren RJ, de Koning HJ, Mulshine J, Hirsch FR. Lung cancer screening by spiral CT. What is the optimal target population for screening trials? Lung Cancer. 2002; 38(3): 243-52.
5. Duffy SW, Raji OY, Agbaje OF, Allgood PC, Cassidy A, Field JK. Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer. Expert Rev Anticancer Ther. 2009; 9(10): 1467-72.
6. Cassidy A, Myles J, van-Tongeren M, Page R, Liloglou T, Duffy S, et al. The LLP risk model: an individual risk prediction model for lung cancer. Br J Cancer. 2008; 98((2)): 270-6.
7. Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. Bmj. 2000; 321(7257): 323-9.
8. Payne S. ‘Smoke like a man, die like a man’?1: A review of the relationship between gender, sex and lung cancer Social Science & Medicine 2001; 53(8): 1067-80
9. Beck U. Risk Society: Towards a New Modernity. London: Sage; 1992.
10. Giddens A. Modernity and self-identity: self and society in the late modern age. Cambridge: Polity Press; 1991.
11. Poland B, Frohlich K, Haines R, Mykhalovskiy E, Rock M, Sparks R. The social context of smoking: the next frontier in tobacco control? Tobacco Control. 2006; 15: 59-63.
12. Bancroft A, Wiltshire S, Parry O, Amos A. "It’s like an addiction first thing… afterwards it's like a habit": daily smoking behaviour among people living in areas of deprivation Social Science & Medicine 2003; 56(6): 1261-7
13. Wiltshire S, Bancroft A, Parry O, Amos A. ‘I came back here and started smoking again’: perceptions and experiences of quitting among disadvantaged smokers Health Education Research. 2003; Vol. 18, No. 3: 292-303.
14. Robinson J, Ritchie D, Amos A, Cunningham-Burley S, Greaves L, Martin C. 'Waiting until they got home': Gender, smoking and tobacco exposure. Social Science & Medicine. 2010; 71: 884-90.
15. Thompson L, Pearce J, Barnett J. Moralising geographies: stigma, smoking islands and responsible subjects. AREA. 2007; 39(4): 508-17.
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