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Prof A Kadioglu
Prof R Pleass
Applications accepted all year round
Self-Funded PhD Students Only
About the Project
Short outline of research project
Streptococcus pneumoniae (the pneumococcus) is a major human pathogen and principle cause of bacterial pneumonia, septicaemia and meningitis worldwide. The pneumococcus is a major cause of infant mortality in developing countries, causing approximately 25% of all preventable deaths in children under the age of 5, with an annual burden of over 1.2 million infant deaths. New targets for therapy and vaccination are urgently required.
This project will investigate the efficacy of various new vaccine candidate pneumocococcal virulence factors in nasopharyngeal colonisation and invasive disease. Fc-fusion proteins have successfully been used to immunise against HIV andHSV viruses (Ye et al, Nature Biotechnology 2011, 29: 158-163). This project aims to investigate this Fc-fusion platform as an antigen delivery system for vaccination against pneumococcal colonisation and invasive pneumonia.
Streptococcus pneumoniae (the pneumococcus) is a major human pathogen and principle cause of bacterial pneumonia, septicaemia and meningitis worldwide. The pneumococcus is a major cause of infant mortality in developing countries, causing approximately 25% of all preventable deaths in children under the age of 5, with an annual burden of over 1.2 million infant deaths. New targets for therapy and vaccination are urgently required.
This project will investigate the efficacy of various new vaccine candidate pneumocococcal virulence factors in nasopharyngeal colonisation and invasive disease. Fc-fusion proteins have successfully been used to immunise against HIV andHSV viruses (Ye et al, Nature Biotechnology 2011, 29: 158-163). This project aims to investigate this Fc-fusion platform as an antigen delivery system for vaccination against pneumococcal colonisation and invasive pneumonia.
Funding Notes
The student needs to have full funding from their sponsor for tuition fees, stipend and bench fees to cover all laboratory consumables costs.
Training element
The project involves cloning bacterial antigens into Fc-fusion plasmid constructs, mammalian cell expression and immunisation studies in mouse models of colonisation and invasive pneumonia as well as determining host immune responses to infection and immunisation. A wide range of molecular, bacteriological, immunological and cutting edge imaging techniques will be used in this PhD project.
Training element
The project involves cloning bacterial antigens into Fc-fusion plasmid constructs, mammalian cell expression and immunisation studies in mouse models of colonisation and invasive pneumonia as well as determining host immune responses to infection and immunisation. A wide range of molecular, bacteriological, immunological and cutting edge imaging techniques will be used in this PhD project.
Project supervisors
Prof A Kadioglu's profile is coming soon
View other supervisors at University of LiverpoolProf R Pleass's profile is coming soon
View other supervisors at University of Liverpool
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