Take our PhD survey
Take our PhD
survey for the
* or equivalent in Euros or US Dollars
22 May, 2013
Browse By Subject
Browse By Region
Professional Development (CPD)
PostDoc & PhD Jobs
PhD Research Project
This project is no longer listed in the FindAPhD database
and may not be available.
Click here to view other PhD studentship opportunities at University of Brighton.
Understanding alterations in cellular signalling during post-natal maturation in the lower bowel
University of Brighton
School of Pharmacy & Biomolecular Sciences
Dr B.A. Patel
Dr M Yeoman
No more applications being accepted
Funded PhD Project (Students Worldwide)
This research project has funding attached. Applications for this project are welcome from suitably qualified candidates worldwide. Funding may only be available to a limited set of nationalities and you should read the full department and project details for further information.
PhD Research Project
Understanding the maturation of the enteric nervous system (ENS) is important as paediatric motility disturbances place a large burden on the affected children and their families. These disorders also place a large burden on the resources of healthcare providers. The ENS begins to mature during embryonic development when neural precursors migrate from the neural crest into the bowel wall. When the neural precursors reach the gastrointestinal GI tract, trophic factors and extracellular matrix proteins stimulate neuronal differentiation and circuit formation. However, the ENS continues to mature in the postnatal period developing pathways and connections that govern its prime function of motility control. Limited information is known about how the different neurotransmitter systems develop during this postnatal period and how this affects signalling at the neuromuscular junction.
This project will test the hypothesis that neurotransmission pathways that innervate the neuromuscular junction develop at various timelines during ENS maturation, causing postnatal changes in motility. The project will use a range of electrochemical, electrophysiological and functional bioassays to study the functional and activity of the ENS. Electrochemical sensors will be used to understand how levels of the key neurochemical (nitric oxide, acetylcholine, serotonin and adenosine tri-phosphate) alter during ENS maturation. Functional bioassays and electrophysiology will be utilised to study the receptor pharmacology and efficacy of the neuromuscular junction.
You will have the opportunity to develop practical skills in sensor fabrication and assessment, biological monitoring, functional bioassays and electrophysiology. The supervisory team for this project will be: Dr Bhavik Patel and Dr Mark Yeoman. Please contact Dr. Bhavik Patel (B.A.Patel@brighton.ac.uk) to discuss project specific details. This studentship is available from October 2012.
3-year funding includes tuition fees plus stipend of £14,300p.a.
Applicants should have a first or 2(i) honours degree in a relevant subject.
Applications can be made online through our Course Finder. Further details are available from Alice Parkes on: 01273 641104 or A.Parkes@brighton.ac.uk or by writing to the Research Student Administrator (P&BS), Doctoral College, Mithras House, Lewes Road, Brighton, BN2 4AT.
All applications should include a copy of your passport, copies of your degree certificates and transcripts to date, of your IELTS/ equivalent English language qualification (where applicable) and 2 references. Please contact the Research Student Administrator for further details.
1. B. A. Patel, Electroanalytical approaches to study signaling mechanisms in the gastrointestinal tract, Neurogastroenetrol. Motil., 2011, 23(7), 595 – 605.
2. B. A. Patel, M. Rogers, T. Wieder, D. O’Hare and M. Boutelle, ATP microelectrode for stable long-term in vitro monitoring from gastrointestinal tract, Biosensors Bioelectronics, 2011, 26, 2890 - 2896.
3. B.A. Patel, Amperometric detection of co-released serotonin and melatonin from the mucosa in the ileum, Analyst., 2008, 133, 516 – 524.
4. X. Bain, B.A. Patel, X. Dai, J.J. Galligan and G.M. Swain, High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression, Gastroenterology, 2007, 132(7), 2438 – 2447.
Like This PhD?
Add To Shortlist
PhD Provider Info
Visit Provider Website
All PhDs in this Dept
Send to a Friend
Printer Friendly Page
View A Larger Map
Modelling the bladder and lower urinary tract
University of Sheffield
Department of Computer Science
Understanding and Communicating Climate Change: Understanding spatio-temporal information in climate change communication
University of East Anglia
Faculty of Social Sciences
Control of apoptosis during cell division and in response to anti-cancer drugs
University of Dundee
Division of Cancer Research, Medical Research Institute
Regulation of signalling molecules in vascular smooth muscle
University of Manchester
Manchester Medical and Human Sciences
Postgraduate Study Fair
MANCHESTER, 20 NOVEMBER 2013
Postgraduate Study & MBA Fair
LONDON, 30 JANUARY 2014
Like FindAPhD for news, events & competitions
Follow us on Twitter
Find A PhD
All rights reserved
Search for PhDs
PhDs by Subject
PhDs by Institution
PhDs by Region
Info for Students
PhD Study Guide
PhDs in the UK
PhD Funding Guide
Postgraduate Advice Forum
Postgraduate Email Updates
Info for Advertisers
Advertise a PhD
Banner & Buttons
Advertisers T & Cs
PostDoc & PhD Jobs
The Science Registry Ltd
, Sellers Wheel, 151 Arundel Street, Sheffield, S1 2NU, United Kingdom. Tel +44 (0) 114 268 4940 Fax: +44 (0) 114 268 5766
Clicking here will add this PhD to your PhD shortlist.
Your PhD shortlist allows you to easily browse, email & save projects and programmes.
Enquiry by Telephone
click to proceed
Enquiry by Email
click to proceed
Apply Online NOW!
click to visit
Add to and from your shortlist
click to add/remove
Click here to view the items added to your shortlist.