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  Action on Hearing Loss Studentship: Animal Model of Tinnitus


   Department of Physiology, Anatomy & Genetics

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Prof A King, Prof V Bajo  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

A PhD studentship is available from October 2012 to work on an animal model of tinnitus with Dr Victoria Bajo and Prof Andrew King in the Auditory Neuroscience Group, Department of Physiology, Anatomy and Genetics. The studentship is funded by Action on Hearing Loss (formerly RNID) and is available from October 2012.

Tinnitus is a prevalent condition with no single cure. In the UK and other Western countries, about 10-15% of the population suffer persistent tinnitus. Most, but not all, cases of chronic tinnitus are associated with hearing loss as a result of the ageing process or acoustic trauma in younger individuals. We aim to identify the relationship between tinnitus and hearing-loss induced cortical plasticity. Using ferrets as an animal model in which tinnitus will be induced by a selective lesion in the spiral ganglion and confirmed by gap detection behaviour, we will examine whether the presence of tinnitus depends on the resulting reorganization of the auditory cortex. We will attempt to identify a potential causal relationship between cortical plasticity and tinnitus by investigating whether gap performance at frequencies bordering the edge of the hearing loss is modified when the reorganized cortical responses are selectively silenced by optogenetic approaches.

The studentship provides a stipend (starting at £15,500 p.a.) and covers University and College fees at the UK/EU rate.

Please contact Victoria Bajo [Email Address Removed] and Andy King [Email Address Removed] for informal enquiries and further details.

Funding Notes

Funded by Action on Hearing Loss (formerly RNID)

References

Eggermont JJ, Roberts LE (2004) The neuroscience of tinnitus. Trends Neurosci. 27: 676-82

Chow BY, Han X, Dobry AS, Qian X, Chuong AS, Li M, Henninger MA, Belfort GM, Lin Y, Monahan PE, Boyden ES (2010) High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature 463: 98-102.

King AJ, Dahmen JC, Keating P, Leach ND, Nodal FR, Bajo VM (2011) Neural circuits underlying adaptation and learning in the perception of auditory space. Neurosci. Biobehav. Rev. 35: 2129-39.
The studentship provides a stipend (starting at £15,500 p.a.) and covers University and College fees at the UK/EU rate..