Find A PhD

Find A Masters

1000's of Masters Courses from across the globe

Find An MBA

MBA & Business Masters courses from the World's leading Business Schools

Spotlight

University of Reading Featured PhD Projects & Programmes

Spotlight

University College London Featured PhD Projects & Programmes
University of Huddersfield Featured PhD Projects & Programmes
Durham University Featured PhD Projects & Programmes

PhD Research Project

Developing High-Resolution Solid-State NMR Methods for the Characterisation of Pharmaceutical Solids


More Info


Institution Location



Related PhDs



University of Warwick
Department of Physics
Dr S P Brown
No more applications being accepted
Funded PhD Project (UK Students Only)

The specific three-dimensional packing of a pharmaceutical molecule in the solid state determines key physical properties, notably bioavailability. As such, the pharmaceutical industry makes significant investment in the characterisation of
different solid-state forms of active pharmaceutical ingredients, including different polymorphs, hydrates and solvates, as well as co-crystals and amorphous dispersions.

Solid-state NMR is a rapidly developing analytical tool that has the advantage of applicability to powdered samples lacking long-range periodic order. In particular, the 1H chemical shift has been shown to be very sensitive to key intermolecular interactions, notably, hydrogen bonding and aromatic pi-pi stacking, which direct the packing of organic molecules.

The project will involve the development and application of high-resolution homonuclear and heteronuclear 1H solid-state NMR experiments that identify close proximities (less than 4Å) between pairs of hydrogen atoms or between a hydrogen atom and a carbon or nitrogen atom, so as to identify, for example, specific intermolecular interactions and packing arrangements. Experiments will be performed in the Warwick Centre for Magnetic Resonance, which houses the biggest concentration of solid-state NMR spectrometers in the UK, including hosting the UK 850 MHz solid-state NMR facility. A combined approach linking experiment with simulation will be employed in the framework of the emerging field of NMR crystallography.

For further information concerning the Warwick NMR group, see:
http://www.go.warwick.ac.uk/nmr/


Funding Notes:

A full 3.5 year studentship for UK students (fees and maintenance) is available. Candidates should hold or expect to hold a high 2.1 or 1st in Physics or related subject area. See http://www2.warwick.ac.uk/fac/sci/physics/prospective/postgraduate/pgintro/projects/priority/ for further details.



Spotlight

National University of Singapore Featured PhD Projects & Programmes

Find A PhD

Copyright ©2005-2014
All rights reserved

FindAPhD is a database of PhD Projects & Programmes

FindA University Ltd, Sellers Wheel, 151 Arundel Street, Sheffield, S1 2NU, UK. Tel: +44 (0)114 213 4333 Fax: +44 (0) 114 268 5766
Cookie Policy    X