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University of Warwick Featured PhD Projects & Programmes [{"Id":48083,"Type":"M","Filename":"menu_york_biol5.gif","Institution":"University of York","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48113,"Type":"M","Filename":"reading-grad.gif","Institution":"University of Reading","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48233,"Type":"M","Filename":"warwick-bus14.gif","Institution":"University of Warwick","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48257,"Type":"M","Filename":"Leeds-Open14.gif","Institution":"University of Leeds","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48370,"Type":"M","Filename":"menu_yorkcomp.gif","Institution":"University of York","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48373,"Type":"M","Filename":"sheff14.gif","Institution":"University of Sheffield","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48432,"Type":"M","Filename":"menu_lanc80A.gif","Institution":"Lancaster University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48458,"Type":"M","Filename":"durham.gif","Institution":"Durham University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""}]

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PhD Research Project

Control of synaptobrevin retrieval by synaptophysin


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Dr M Cousin
No more applications being accepted
Competition Funded PhD Project (UK Students Only)

Synaptobrevin-2 and synaptophysin are the two most abundant proteins present on a synaptic vesicle (SV). Synaptobrevin-2 is a protein essential for SV exocytosis, whereas until recently synaptophysin was a protein of unknown function. We have recently shown that synaptophysin is essential for the specific retrieval of synaptobrevin-2 from the plasma membrane after exocytosis, however may questions remain unanswered. These include, what controls the retrieval of synaptophysin itself, how does synaptophysin interact with synaptobrevin-2, and does synaptophysin also control the retrieval of non-canonical synaptobrevins (thought to define different modes of exocytosis)? Approaches used will include primary neuronal cultures derived from synaptophysin knockout mice, monitoring of SV recycling using fluorescent genetic and chemical reporters, ultrastructural analysis using transmission electron microscopy, recombinant protein expression, classical biochemistry and molecular biology technologies.


References:

Gordon S.L., Leube R.E. and Cousin M.A. (2011) Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosis J. Neurosci. 31: 14032-14036.
Clayton E.L., Sue N., Smillie K.J., O’Leary T., Bache N., Cheung G., Cole, A.R., Wyllie D.J, Sutherland C., Robinson P.J. and Cousin M.A. Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles. (2010) Nature Neurosci. 13: 845-851.




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National University of Singapore Featured PhD Projects & Programmes [{"Id":47724,"Type":"SS","Filename":"nus-ngs14c.gif","Institution":"National University of Singapore","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48276,"Type":"SS","Filename":"bath14.gif","Institution":"University of Bath","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48278,"Type":"SS","Filename":"Leeds-scholar15.gif","Institution":"University of Leeds","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48374,"Type":"SS","Filename":"manc-herc14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48438,"Type":"SS","Filename":"bristol-sphere14.gif","Institution":"University of Bristol","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48439,"Type":"SS","Filename":"liverpool-open14a.gif","Institution":"University of Liverpool","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48446,"Type":"SS","Filename":"bham-nerc.gif","Institution":"University of Birmingham","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48461,"Type":"SS","Filename":"bham-25scholb.gif","Institution":"University of Birmingham","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""}]

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