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Emergence of synaptic dysfunction in Alzheimer's disease.

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Project Description

A fully funded PhD studentship in Applied Neuroscience is available to work with Dr. Mariana Vargas-Caballero and Prof. Hugh Perry at the University of Southampton.

Although our understanding of Alzheimer's disease has greatly increased in the last few decades, there is currently still no effective therapy that can modify disease progression. Our current knowledge suggests that this disease initially impacts on synapse integrity in the brain: the mechanisms, however, are not well understood. You will use a combination of behavioural and electrophysiological experiments to link the emergence of memory impairment with synaptic function and dysfunction in a mouse model of Alzheimer's disease.

The University of Southampton provides an outstanding environment for research on dementia. The interdisciplinary programme of research is integrated across the disciplines of biology and medicine including laboratories with clinical and non-clinical expertise. The Institute for Life Sciences represents a University-wide multidisciplinary collaboration drawing together expertise in science and engineering, with a shared goal to apply novel discoveries to the outstanding challenges of science.

Candidates must have, or expect to gain, a first or strong upper second-class degree or equivalent, in an appropriate discipline.

Funding Notes

Start date: October 2013.
Funding: The studentship is funded by the Kerkut Trust and the Institute for Life Sciences for 3 years. The stipend is to be funded at RCUK level, currently £14,140 per annum. The studentship is open to British and EU nationals only. International students can apply but they must be able to meet the difference between home/EU and International tuition fees themselves.


Interviews are expected to take place on 20th February 2013.

Please send CV, personal statement, and contact details of two referees to:

Related Subjects

How good is research at University of Southampton in Biological Sciences?

FTE Category A staff submitted: 34.80

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities
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