Event Countdown: FindAPhD Live!
0
5
DAYS
0
1
HOURS
3
7
MINS
[close]

Find A PhD

Find A Masters

1000's of Masters Courses from across the globe

Find An MBA

MBA & Business Masters courses from the World's leading Business Schools

Spotlight

Ludwig-Maximilians-Universität Munich Featured PhD Projects & Programmes [{"Id":47905,"Type":"M","Filename":"manchester-computer14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48046,"Type":"M","Filename":"bham-distance14.gif","Institution":"University of Birmingham","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48083,"Type":"M","Filename":"menu_york_biol5.gif","Institution":"University of York","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48107,"Type":"M","Filename":"menu_manchester14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48113,"Type":"M","Filename":"reading-grad.gif","Institution":"University of Reading","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48179,"Type":"M","Filename":"menu_munich.gif","Institution":"Ludwig-Maximilians-Universität Munich","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48233,"Type":"M","Filename":"warwick-bus14.gif","Institution":"University of Warwick","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48253,"Type":"M","Filename":"menu-abdopen.gif","Institution":"Aberdeen University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""}]

Spotlight

FindA University Ltd Featured PhD Projects & Programmes
University of Cambridge Featured PhD Projects & Programmes
Max Planck Featured PhD Projects & Programmes
[{"Id":47596,"Type":"L","Filename":"cardiff-open14.gif","Institution":"Cardiff University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":47668,"Type":"L","Filename":"/ucl-imaging13.gif","Institution":"University College London","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":47923,"Type":"L","Filename":"epsrc2014.gif","Institution":"EPSRC","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":47992,"Type":"L","Filename":"fap-live14.gif","Institution":"FindA University Ltd","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48165,"Type":"L","Filename":"soton-chem14.gif","Institution":"University of Southampton","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48166,"Type":"L","Filename":"soton-bios14.gif","Institution":"University of Southampton","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48192,"Type":"L","Filename":"tmcs-epsrcB.gif","Institution":"University of Bristol","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48211,"Type":"L","Filename":"impchem14.gif","Institution":"Imperial College London","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48238,"Type":"L","Filename":"cancer-mrc1.gif","Institution":"University of Cambridge","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48244,"Type":"L","Filename":"cardiff-Engineer.gif","Institution":"Cardiff University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48246,"Type":"L","Filename":"cruk14.gif","Institution":"Cancer Research UK","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48252,"Type":"L","Filename":"sussex-neuro2013.gif","Institution":"University of Sussex","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48258,"Type":"L","Filename":"kcl-iop14.gif","Institution":"King’s College London","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48265,"Type":"L","Filename":"wellcome-sanger14.gif","Institution":"University of Cambridge","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48266,"Type":"L","Filename":"nrp-rotation14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48267,"Type":"L","Filename":"nrp-dtp14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48268,"Type":"L","Filename":"nrp-ifr14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48269,"Type":"L","Filename":"nrp-TGAC14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48270,"Type":"L","Filename":"nrp-JIC14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48271,"Type":"L","Filename":"nrp-TSL14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48274,"Type":"L","Filename":"oxford-biochem.gif","Institution":"University of Oxford","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48288,"Type":"L","Filename":"maxplanck14.gif","Institution":"Max Planck","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""}]

PhD Research Project

Investigating hotspots of telomere fusion activity with genomic loci


More Info


Institution Location



Related PhDs


Peter MacCallum Cancer Centre
Sir Peter MacCallum Department of Oncology, University of Melbourne
University of Cambridge
Department of Plant Sciences
University of Birmingham
School of Biosciences
University of Oxford
Department of Oncology

Cardiff University
Cardiff School of Medicine
Dr D Baird
Dr K Liddiard
No more applications being accepted

The work in our lab is primarily concerned with the dynamics of human telomeric DNA from the standpoints of genetic disease, the ageing process and cancer.
Currently we are focusing on the mechanistic basis of telomere erosion, instability and how the loss of telomere function could drive cancer progression. Dysfunctional telomeres may either trigger replicative senescence or undergo fusion with other chromosome ends or non-telomeric DNA breaks. We have been examining the mechanisms underlying telomere fusion (1-3) and how this process can drive genomic instability creating the types of lesions commonly found in human tumours (4-5).
A key component of this work is to understand the extent to which telomeres undergo fusion with non-telomeric loci and to identify the specific features of the genomic loci that are prone to fuse with telomeres (2).
This fully funded 3-year PhD project will focus using our single-molecule approaches to detect rare mutation event to characterise fusion hotspots throughout the genome. This work will help define the molecular features of genomic sequences with a propensity to undergo fusion with dysfunctional telomeres.

We are looking for a highly motivated and enthusiastic student with great interest in telomere biology and cancer genetics. Experience in molecular biology techniques and basic bioinformatics and genomics will be an asset. Informal enquiries can be address to Prof. Baird at bairddm@cardiff.ac.uk.

The successful candidate will be part of the Professor Baird's internationally-recognised telomere research group within the Institute of Cancer and Genetics at Cardiff University, which has an outstanding reputation for cancer research.


CV and Covering Letter required in the first instance - please email ICG-Recruitment@cardiff.ac.uk


Funding Notes:

UK/EU tuition fees only (if applicable, any eligible non-EU candidates must fund the remainder of the overseas fee)

Doctoral Stipend matching UK Research Council National Minimum (£13,590 p.a. for 2012/13, updated each year)


References:

1. Capper, R., Britt-Compton, B., Tankimanova, M., Rowson, J., Letsolo, B., Man, S., Haughton, M. and Baird, D.M. The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes and Development 21: 2495-2508 (2007)

2 Letsolo, B. T., Rowson, J. and Baird, D. M. Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Research 38: 1841-1852 (2010).

3. Tankimanova, M., Capper, R., Letsolo, B. T., Rowson, J., Jones, R., Britt-Compton, B., Taylor, A. M. R. and Baird, D. M. Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Research 40: 2518-2526 (2012)

4. Lin, T. T., Letsolo, B. T., Jones, R. E., Rowson, J., Pratt, G., Hewamana, S., Fegan, C., Pepper, C. and Baird, D. M. Telomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis. Blood 116: 1899-1907 (2010).



PhD Scholarships

FindAPhD Scholarship available for this PhD opportunity!

We are offering students wishing to start their postgraduate studies in autumn 2015 at any university listed on FindAPhD.com the chance of winning a £5,000 PhD scholarship. We will also be awarding a number of £500 scholarships

Register your interest here


Spotlight

University of Manchester Featured PhD Projects & Programmes [{"Id":47724,"Type":"SS","Filename":"nus-ngs14c.gif","Institution":"National University of Singapore","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":47993,"Type":"SS","Filename":"lond-fair-oct14.gif","Institution":"FindA University Ltd","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48106,"Type":"SS","Filename":"manc-bbsrc14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48109,"Type":"SS","Filename":"manc-epsrc14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48263,"Type":"SS","Filename":"kyushu-IEI.gif","Institution":"Kyushu University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""}]

Find A PhD

Copyright ©2005-2014
All rights reserved

FindAPhD is a database of PhD Projects & Programmes

FindA University Ltd, Sellers Wheel, 151 Arundel Street, Sheffield, S1 2NU, UK. Tel: +44 (0)114 213 4333 Fax: +44 (0) 114 268 5766
Cookie Policy    X