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PhD Research Project

DNA repair and meiosis control in mammalian oocytes


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Institution Location



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University of Edinburgh
Cell and Molecular Biology

Biological Sciences
Prof K Jones
No more applications being accepted

Applications are invited for a 3 Year fully funded studentship commencing in Autumn 2013.

The PHD studentship is offered in the laboratory of Professor Keith Jones to work on the control of meiosis in mammalian oocytes. The post would ideally suit someone graduating from a UK or EU University in 2013, who has interests in cell biology. The project will investigate how the meiotic divisions of the oocyte are controlled. There will be a focus on studying chromosomes, and cell cycle processes. We are particular keen to pursue how DNA repair is conducted in oocytes. This is because increasing numbers of women now survive cancer treatment, and there is a great desire to maintain their fertility once their treatment is complete. However, our understanding of DNA repair processes in oocytes is weak.

The successful candidate will likely use confocal microscopy and other imaging based techniques. The work would be conducted in Building 85, a new research building housing the Institute for Life Sciences, at the heart of the main, Highfield Campus of the University. The posts may suit students wishing to pursue a career in cell cycle regulation.


Funding Notes:

This positon would suit someone who has a biological sciences degree background, with strengths in biochemistry, cell biology or genetics. The student must hold, or expect to obtain, and upper second or first class degree in a relevant subject. Due to funding restrictions, this studentship are only open to UK applicants


References:

Jones KT & Lane SI (2012) Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytes. Experimental Cell Research, 318: 1394-1399



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